Pacira Pharmaceuticals, Inc. is a leading American public pharmaceutical company that specializes in the development, marketing and commercialization of proprietary products for patients and healthcare providers. Their aim is to improve patients' outcomes through the development of non-opioid pain management options, primarily in the United States. One of their most popular products is Exparel (bupivacaine liposome injectable suspension), which is a local anesthetic that is used to relieve severe pain in various surgical procedures. In this article, we will explore the uses, dosage, side effects, interactions, generics and demographics of Pacira. Uses Exparel provided by Pacira is a local anesthetic that is used for a single-dose infiltration into the surgical site to relieve postsurgical pain. It is especially effective in orthopedic, bariatric, colorectal, and plastic surgery procedures. Exparel is the first formulation of bupivacaine designed to provide long-acting pain relief for up to 72 hours after surgery, thereby potentially reducing the need for opioid medications. In addition to its use in surgical procedures, Exparel has also been used in the management of chronic pain such as postsurgical pain, neuropathic pain, and posttraumatic pain. Dosage The dosage of Exparel for local infiltration varies depending on the size of the surgical site. It is generally used as a single dose protocol ranging from 133 mg to 532 mg, with a maximum dose of 266 mg per 92 cm^2. The dosage may also vary depending on the patient's age, weight, and medical history. It should be administered by a trained healthcare provider. Side effects Like every medication, Exparel has potential side effects. These may include nausea, vomiting, headache, fatigue, sweating, constipation, and itching. In rare cases, Exparel may also cause an allergic reaction to patients with a hypersensitive response to amide-type local anesthetics. Patients should inform their healthcare provider if they have experienced such an allergic response in the past. Regular monitoring of vital signs is critical when administering Exparel. Interactions Patients taking Exparel should inform their healthcare provider of all their current medications, including prescription, over-the-counter, and herbal supplements. Drugs that may interact with Exparel include other local anesthetics, medications that can prolong the QT interval, and medications that inhibit CYP3A4, such as ketoconazole, clarithromycin, and erythromycin. Alcohol should be avoided as it can increase the risk of CNS depression. Generic Exparel is the only formulation of bupivacaine liposome injectable suspension approved by the U.S. Food and Drug Administration (FDA) for a single-dose infiltration. However, some generic formulations of bupivacaine may exist. Demographics Exparel is indicated for use in adults, aged 18 years and over. It is used in various surgical procedures, predominantly in the United States. In recent years, there has been a growing interest in non-opioid pain management options, and Exparel has become an increasingly popular alternative to opioids. Conclusion Exparel, developed by Pacira Pharmaceuticals, has revolutionized postsurgical pain management for many patients. As an alternative to opioids, it provides long-acting pain relief for up to 72 hours, potentially reducing the need for opioid medications. However, Exparel does have potential side effects and drug interactions, which should be monitored by a healthcare provider. Despite the potential risks, Exparel has been a game-changer in pain management, especially in various surgical procedures.