Orexigen Therapeutics is a pharmaceutical company that focuses on the development and commercialization of innovative therapies for the treatment of obesity. The company's main product is Contrave, which is a combination of two drugs, bupropion and naltrexone, that work together to curb appetite and reduce food cravings. Here's what you need to know about Orexigen Therapeutics and Contrave. Uses Contrave is used to help overweight or obese adults lose weight. It is meant to be used in conjunction with a reduced-calorie diet and increased physical activity. Contrave is designed for people who have a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with at least one weight-related medical condition, such as high blood pressure, type 2 diabetes, or high cholesterol. Dosage The recommended dosage of Contrave is two tablets taken twice a day. The tablets should be taken with food to reduce the risk of nausea. It is important to follow the dosage instructions provided by your healthcare provider and not to exceed the recommended dose. Side Effects Like all medications, Contrave can cause side effects. The most common side effects reported in clinical trials include nausea, constipation, headache, vomiting, dizziness, and dry mouth. These side effects are usually mild and go away on their own. If you experience any severe or persistent side effects, you should contact your healthcare provider right away. Interactions Contrave can interact with other medications, especially if they affect the same neurotransmitters in the brain. It is important to inform your healthcare provider of all medications and supplements you are taking, especially if you are taking antidepressants, opioids, or any medications that affect blood pressure. Contrave may also interact with alcohol, so it is important to avoid alcohol while taking this medication. Generic Contrave is a combination drug that contains both bupropion and naltrexone. The generic forms of these drugs are available separately, but there is currently no generic version of Contrave available on the market. Demographics Contrave is approved for use in adults over the age of 18. It is not recommended for use in children or adolescents. It is also not recommended for use in pregnant or breastfeeding women, as the safety of the medication during pregnancy and lactation has not been established. Conclusion In summary, Contrave is a combination drug developed and marketed by Orexigen Therapeutics for the treatment of obesity. It is designed for use in overweight or obese adults who have a BMI of 30 or higher or a BMI of 27 or higher with at least one weight-related medical condition. Common side effects of Contrave include nausea, constipation, headache, and dry mouth. It is important to inform your healthcare provider of all medications and supplements you are taking and to follow the dosing instructions provided. Contrave is not recommended for use in children or adolescents, pregnant or breastfeeding women, or those with certain medical conditions.