TRANDOLAPRIL/VERAPAMIL EXTENDED-RELEASE - ORAL

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TRANDOLAPRIL/VERAPAMIL EXTENDED-RELEASE - ORAL

PHONETIC PRONUNCIATION: (tran-DOL-a-pril/ver-AP-a-mil)

COMMON BRAND NAME(S): Tarka

GENERIC NAME(S): trandolapril/verapamil HCl

Uses

USES: This product is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains 2 medications: trandolapril and verapamil. Trandolapril belongs to a class of drugs known as ACE inhibitors. Verapamil belongs to a class of drugs known as calcium channel blockers. They both work by relaxing blood vessels so blood can flow more easily. Verapamil may also lower your heart rate.


How to use TRANDOLAPRIL/VERAPAMIL EXTENDED-RELEASE - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking trandolapril/verapamil and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with food as directed your doctor, usually once or twice daily. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. The dosage is based on your medical condition and response to treatment. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased. It may take up to several weeks before you get the full benefit of this medication. Tell your doctor if your condition does not get better or if it gets worse (your blood pressure readings remain high or increase).

Side Effects

SIDE EFFECTS: Dizziness, lightheadedness, or tiredness may occur as your body adjusts to the medication. Dry cough, constipation, or nausea may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: fainting, new or worsening symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), signs of kidney problems (such as change in the amount of urine). This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking this product, tell your doctor or pharmacist if you are allergic to trandolapril or verapamil; or to other ACE inhibitors (such as benazepril, lisinopril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart rhythm problems (such as second- or third-degree atrioventricular block, sick sinus syndrome unless you have a pacemaker, Wolff-Parkinson-White syndrome, Lown-Ganong-Levine syndrome), certain types of heart problems (such as aortic stenosis, heart failure), certain muscle/nerve disorders (muscular dystrophy, myasthenia gravis), history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), liver disease, kidney disease, high level of potassium in the blood. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise. This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially dizziness, increases in potassium level, constipation, swelling ankles/feet, and change in the amount of urine (kidney problems). This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. See also Warning section. Verapamil passes into breast milk. It is unknown if trandolapril passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: See also Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: aliskiren, clonidine, disopyramide, dofetilide, dolasetron, fingolimod, gold injections, lithium, sacubitril, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone). Other medications can affect the removal of verapamil from your body, which may affect how this product works. Examples include erythromycin, rifamycins (such as rifampin), ritonavir, St. John's wort, among others. Verapamil can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include asunaprevir, colchicine, flibanserin, ivabradine, lomitapide, midazolam, triazolam, among others. Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking trandolapril/verapamil. Make sure all your doctors know which medicines you are using.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting, very slow heartbeat.

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Faq for TRANDOLAPRIL/VERAPAMIL EXTENDED-RELEASE - ORAL

Trandolapril/Verapamil Extended-Release is used to treat high blood pressure (hypertension). It combines two medications, trandolapril and verapamil, to help lower blood pressure and improve blood flow.

Trandolapril/Verapamil Extended-Release works by relaxing the blood vessels and reducing the workload on the heart. Verapamil blocks calcium channels, which helps in the relaxation of blood vessels, while trandolapril inhibits the production of certain chemicals that narrow the blood vessels.

The common side effects of Trandolapril/Verapamil Extended-Release may include constipation, dizziness, headache, nausea, cough, and tiredness. Consult your doctor if these side effects persist or worsen.

If you miss a dose, take it as soon as you remember. However, if it is closer to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

It is generally recommended to avoid alcohol while taking Trandolapril/Verapamil Extended-Release. Alcohol may increase the side effects of these medications, such as dizziness and drowsiness. Consult your doctor or pharmacist for specific advice regarding alcohol consumption.

Trandolapril/Verapamil Extended-Release should not be used during pregnancy as it may harm the unborn baby. It is also not recommended during breastfeeding since both trandolapril and verapamil can pass into breast milk. Consult your healthcare provider for alternative medications or if you have concerns.

Trandolapril/Verapamil Extended-Release can interact with other medications, including but not limited to potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, certain antifungal drugs, and grapefruit juice. Inform your doctor about all the medications, supplements, and herbal products you are taking to prevent any potential interactions.

The exact time it takes for Trandolapril/Verapamil Extended-Release to start working may vary from person to person. However, some individuals may start experiencing a reduction in blood pressure within a few hours, while it may take several weeks for the full effects to be noticed.

No, you should not crush, split, or chew Trandolapril/Verapamil Extended-Release tablets. They are specifically designed to release the medication slowly over time. Breaking the tablets may interfere with the controlled release mechanism, affecting the effectiveness of the medication.

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Warning

WARNING: Trandolapril can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this product. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this product. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.