SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR - ORAL

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SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR - ORAL

PHONETIC PRONUNCIATION: (soe-FOS-bue-vir/vel-PAT-as-vir/VOX-i-LA-pre-vir)

COMMON BRAND NAME(S): Vosevi

GENERIC NAME(S): sofosbuvir/velpatasvir/voxilaprevir

Uses

USES: This medication contains 3 drugs: sofosbuvir, velpatasvir, and voxilaprevir. This medication is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. It is not known if this treatment can prevent you from passing the virus to others. Do not share needles, and practice "safer sex" (including the use of latex condoms) to lower the risk of passing the virus to others.


How to use SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking sofosbuvir/velpatasvir/voxilaprevir and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with food as directed by your doctor, usually once daily. This medication works best when the amount of drug in your body is kept at a constant level. Take this drug at evenly spaced times. To help you remember, take it at the same time each day. Continue to take this medication for the full length of time prescribed, even if symptoms disappear after a short time. Stopping the medication too early may result in a return of the infection. Antacids lower the absorption of velpatasvir. If you are taking an antacid, take it at least 4 hours before or 4 hours after this medication. Other acid-lowering medications for indigestion, heartburn, or ulcers (such as prescription or over-the-counter medications including famotidine, omeprazole) may prevent velpatasvir from working. Ask your doctor or pharmacist how to use these medications safely.

Side Effects

SIDE EFFECTS: See also Warning section. Tiredness, headache, nausea, diarrhea, or difficulty sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to sofosbuvir or velpatasvir or voxilaprevir; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, other liver problems (such as hepatitis B). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: amiodarone. This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include pitavastatin, rosuvastatin, topotecan, among others. Other medications can affect the removal of this medication from your body, which may affect how this medication works. Examples include atazanavir, cyclosporine, efavirenz, lopinavir, rifamycins (such as rifampin, rifabutin), St. John's wort, tipranavir/ritonavir, drugs used to treat seizures (such as phenobarbital, carbamazepine, phenytoin, primidone), among others. Do not take this medication with other products that contain sofosbuvir or velpatasvir.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

VOSEVI 400-100-100 MG TABLET
VOSEVI 400-100-100 MG TABLET
color
beige
shape
oblong
imprint
GSI, logo

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Faq for SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR - ORAL

Sofosbuvir/Velpatasvir/Voxilaprevir is an oral medication used to treat chronic hepatitis C virus (HCV) infection. It is specifically used for HCV genotypes 1-6 in adults.

The medication is a combination of three direct-acting antiviral agents that work together to target different stages of the HCV replication process. Sofosbuvir inhibits the HCV NS5B polymerase, Velpatasvir targets the HCV NS5A protein, and Voxilaprevir inhibits the HCV NS3/4A protease.

The usual dose for Sofosbuvir/Velpatasvir/Voxilaprevir is one tablet taken orally once daily with food. The recommended treatment duration is usually 12 weeks.

The most common side effects of Sofosbuvir/Velpatasvir/Voxilaprevir include headache, fatigue, diarrhea, and nausea. It is important to discuss any persistent or severe side effects with your healthcare provider.

Yes, Sofosbuvir/Velpatasvir/Voxilaprevir can interact with certain medications, including HIV protease inhibitors, anticonvulsants, and certain antifungal medications. It is crucial to inform your doctor about all the medications you are taking to prevent any potential interactions.

It is generally recommended to avoid Sofosbuvir/Velpatasvir/Voxilaprevir during pregnancy unless the potential benefits outweigh the risks. The safety of this medication during breastfeeding is not well-established, and it is advisable to consult with your healthcare provider.

If you forget to take a dose, take it as soon as you remember, and then continue with your regular dosing schedule. Do not double the dose to make up for a missed dose.

Sofosbuvir/Velpatasvir/Voxilaprevir has shown high cure rates for most patients with HCV infection. Clinical studies have demonstrated sustained virologic response rates above 90% in patients treated with this combination.

Sofosbuvir/Velpatasvir/Voxilaprevir has the potential to cure hepatitis C infection in many patients. However, it is important to complete the full treatment course and follow up with your healthcare provider to confirm sustained virologic response and monitor for any potential relapse.

SOFOSBUVIR/VELPATASVIR/VOXILAPREVIR - ORAL Pricing Page Get Discount Coupon

Warning

WARNING: Although this medication helps many people with hepatitis C, it may cause people who also have another liver problem called hepatitis B to get worse. Before starting this medication, tell your doctor if you have ever had hepatitis B. Tell your doctor right away if you have new or worsening symptoms of liver disease, such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, dark urine or yellowing eyes/skin.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.