SIPULEUCEL-T - INJECTION

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SIPULEUCEL-T - INJECTION

PHONETIC PRONUNCIATION: (SI-pu-LOO-sel-tee)

COMMON BRAND NAME(S): Provenge

GENERIC NAME(S): sipuleucel-T/lactated ringers solution

Uses

USES: This medication is used to treat advanced prostate cancer. Sipuleucel-T is a type of vaccine created from your own immune system cells that works by causing your immune system to attack prostate cancer cells. This requires that you have a procedure to remove some of your white blood cells, which are used to prepare sipuleucel-T. Talk to your doctor about the risks and benefits of this treatment.


How to use SIPULEUCEL-T - INJECTION

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using sipuleucel-T and each time you get a refill. If you have any questions, ask your doctor or pharmacist. This medication is created specifically for you from your own blood and should not be given to another patient. Three days before your dose you will have a procedure in which your own white blood cells are removed and then used to create sipuleucel-T. Sipuleucel-T is given as a slow infusion into a vein by a health care professional, roughly every 2 weeks for a total of 3 doses, as directed by your doctor. Your doctor may prescribe premedications (such as acetaminophen, antihistamines) to lessen infusion reactions (see also Side Effects section). These medications are usually given 30 minutes before your dose of sipuleucel-T. To get the most benefit from this medication, do not miss any doses. To help you remember, mark the days on the calendar when you need to receive the medication.

Side Effects

SIDE EFFECTS: Headache, sweating, muscle aches, or back pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Symptoms of an infusion reaction that may occur during sipuleucel-T treatment include chills, tiredness, fever, nausea, vomiting, shortness of breath, fast/irregular heartbeat, and joint pain. Tell your health care professional right away if you have any of these symptoms during or after receiving your treatment. Your doctor will have you monitored closely and may slow the infusion or temporarily stop your treatment if a severe reaction occurs. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: weakness on one side of the body, confusion, slurred speech. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using sipuleucel-T, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems, lung problems, history of stroke. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Sipuleucel-T is not recommended for use by women.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for SIPULEUCEL-T - INJECTION

Sipuleucel-T injection is a type of immunotherapy used for the treatment of advanced prostate cancer. It is a personalized cellular therapy that stimulates the patient's immune system to target and attack the cancer cells.

Sipuleucel-T works by collecting immune cells from the patient's blood and modifying them in a laboratory. These modified cells are then infused back into the patient's body, where they stimulate the immune system to recognize and attack prostate cancer cells.

Sipuleucel-T injection is approved for the treatment of patients with advanced prostate cancer that has spread to other parts of the body and is resistant to hormonal therapy. Your healthcare provider can determine if you are a suitable candidate for this treatment.

The most common side effects of sipuleucel-T injection include chills, fever, fatigue, back pain, nausea, joint ache, and headache. These side effects are usually mild and temporary.

Sipuleucel-T injection is administered through a series of intravenous infusions over a course of several weeks. Each individual treatment session takes about one hour, and the complete treatment regimen typically involves three infusions separated by two-week intervals.

Sipuleucel-T injection is not a cure for prostate cancer, but it has been shown to extend overall survival in patients with advanced prostate cancer. It is considered a treatment option that can help slow down the progression of the disease and increase survival time.

There are other treatment options available for advanced prostate cancer, including chemotherapy, targeted therapy, and hormonal therapy. The choice of treatment depends on various factors such as the stage of cancer, general health, and individual preferences. Your healthcare provider can discuss the possible alternatives with you.

Sipuleucel-T injection has not been shown to have any significant drug interactions. However, it is important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking to ensure safety and to avoid any potential interactions.

Clinical studies have shown that sipuleucel-T injection can extend overall survival in patients with advanced prostate cancer. However, individual responses may vary, and it is important to discuss the potential benefits and risks of the treatment with your healthcare provider.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.