SELEXIPAG - ORAL

PHONETIC PRONUNCIATION: (se-LEX-i-pag)

COMMON BRAND NAME(S): Uptravi

GENERIC NAME(S): selexipag

Uses

USES: Selexipag is used to treat high blood pressure in the lungs (pulmonary arterial hypertension-PAH). It is used to help slow down worsening of PAH and to decrease the chance of needing treatment in a hospital. Selexipag works by making it easier for blood to flow through the arteries in your lungs. This effect helps increase your ability to exercise.

How to use SELEXIPAG - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking selexipag and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually twice daily. Taking this medication with food may lessen stomach upset. The manufacturer directs not to split, crush, or chew the tablet before taking it. However, many similar drugs (immediate-release tablets) can be split, crushed, or chewed. Follow your doctor's directions on how to take this medication. The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Tell your doctor if your condition does not get better or if it gets worse.

Side Effects

SIDE EFFECTS: Headache, nausea, vomiting, diarrhea, loss of appetite, flushing, jaw pain, joint/muscle pain, or pain in your arms or legs may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using selexipag, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of selexipag from your body, which may affect how selexipag works. An example is gemfibrozil.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

UPTRAVI 200 MCG TABLET

color: light yellow
shape: round
imprint: 2

UPTRAVI 200 MCG TABLET

color: light yellow
shape: round
imprint: 2

UPTRAVI 400 MCG TABLET

color: red
shape: round
imprint: 4

UPTRAVI 600 MCG TABLET

color: light violet
shape: round
imprint: 6

UPTRAVI 800 MCG TABLET

color: green
shape: round
imprint: 8

UPTRAVI 1,000 MCG TABLET

color: orange
shape: round
imprint: 10

UPTRAVI 1,200 MCG TABLET

color: dark violet
shape: round
imprint: 12

UPTRAVI 1,400 MCG TABLET

color: dark yellow
shape: round
imprint: 14

UPTRAVI 1,600 MCG TABLET

color: brown
shape: round
imprint: 16

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Faq for SELEXIPAG - ORAL

What is selexipag

Selexipag is an oral medication used to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs.

How does selexipag work

Selexipag works by activating receptors called prostacyclin receptors in the blood vessels of the lungs. This activation leads to relaxation and widening of the blood vessels, reducing the pressure on the arteries and improving blood flow.

What are the common side effects of selexipag

Common side effects of selexipag include headache, diarrhea, nausea, jaw pain, muscle pain, flushing, and joint pain.

How is selexipag taken

Selexipag is taken orally, usually twice daily with or without food. The dosage is typically started low and gradually increased as tolerated.

How long does it take for selexipag to work

The effects of selexipag may start to be seen within a few weeks of starting treatment. However, it may take several months to experience the full benefits of the medication.

Can selexipag be used in children

Selexipag is not recommended for use in children under 18 years of age, as safety and efficacy in this population have not been established.

Can selexipag be used during pregnancy

Selexipag is classified as a pregnancy category B drug, which means it has not been shown to cause harm to the fetus in animal studies. However, its safety in pregnant women has not been extensively studied. It should only be used in pregnancy if the potential benefits outweigh the potential risks.

What should I do if I miss a dose of selexipag

If you miss a dose of selexipag, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Can selexipag be taken with other medications

Selexipag may interact with certain medications, including strong inhibitors or inducers of the CYP2C8 enzyme. It is important to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, before starting selexipag.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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