RUXOLITINIB - ORAL

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RUXOLITINIB - ORAL

PHONETIC PRONUNCIATION: (RUX-oh-LI-ti-nib)

COMMON BRAND NAME(S): Jakafi

GENERIC NAME(S): ruxolitinib phosphate

Uses

USES: This medication is used to treat certain bone marrow disorders (myelofibrosis, polycythemia vera). It works by blocking your body from producing substances called growth factors. Growth factors cause cells to grow and divide, and cause the blood cell and spleen problems found in these disorders. Ruxolitinib belongs to a class of drugs known as JAK inhibitors. Though not a cure for these disorders, ruxolitinib may help with some of the symptoms, including abdominal discomfort, pain under left ribs, early feelings of fullness from meals, night sweats, itching, and bone/muscle pain.


How to use RUXOLITINIB - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking ruxolitinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually twice daily. If you are unable to swallow the tablets, ask your doctor about other ways to take this medication. The dosage is based on your medical condition, laboratory test results, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Do not stop taking ruxolitinib without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as fever, trouble breathing, dizziness, and unusual bleeding/bruising. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away. Tell your doctor if your symptoms do not improve or if they worsen.

Side Effects

SIDE EFFECTS: Dizziness, headache, weight gain, or gas may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk. Tell your doctor right away if you have any serious side effects, including: unusual tiredness, easy bleeding/bruising, unusual skin changes. This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, cough, painful skin rash/blisters, persistent sore throat). This medication may also increase your risk of getting a rare but very serious (sometimes fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if any of these rare but very serious side effects occur: clumsiness, loss of coordination, weakness, sudden change in your thinking (such as confusion, difficulty concentrating), difficulty moving your muscles, problems with speech, seizure, vision changes. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking ruxolitinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/past/returning infections (such as tuberculosis), kidney disease, liver disease, skin cancer. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Ruxolitinib can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu, tuberculosis). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using this drug and for 2 weeks after stopping treatment. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab).

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

JAKAFI 5 MG TABLET
JAKAFI 5 MG TABLET
JAKAFI 5 MG TABLET
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JAKAFI 10 MG TABLET
JAKAFI 10 MG TABLET
JAKAFI 10 MG TABLET
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JAKAFI 15 MG TABLET
JAKAFI 15 MG TABLET
JAKAFI 15 MG TABLET
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JAKAFI 20 MG TABLET
JAKAFI 20 MG TABLET
JAKAFI 20 MG TABLET
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JAKAFI 25 MG TABLET
JAKAFI 25 MG TABLET
JAKAFI 25 MG TABLET
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Faq for RUXOLITINIB - ORAL

Ruxolitinib is an oral medication that belongs to a class of drugs called Janus kinase (JAK) inhibitors. It is used to treat certain blood disorders and inflammatory conditions.

Ruxolitinib is primarily used to treat myelofibrosis, a rare bone marrow disorder. It is also approved for the treatment of polycythemia vera, a condition characterized by the overproduction of red blood cells, and steroid-refractory acute graft-versus-host disease in patients who have received a stem cell transplant.

Ruxolitinib works by inhibiting the activity of JAKs, which are enzymes involved in cell signaling processes. By blocking JAKs, ruxolitinib reduces the production of certain cytokines and growth factors, leading to the improvement of symptoms associated with the treated conditions.

The common side effects of ruxolitinib may include headache, dizziness, nausea, diarrhea, constipation, fatigue, and increased cholesterol levels. It is important to discuss any side effects with your healthcare provider.

Ruxolitinib is taken orally as a tablet. The dosage and frequency of administration will be determined by your healthcare provider based on your specific condition. It is important to follow the prescribed instructions and not exceed the recommended dose.

It is important to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements. Some medications may interact with ruxolitinib, so it is crucial to discuss potential drug interactions with your healthcare provider before starting ruxolitinib.

The effectiveness of ruxolitinib varies depending on the underlying condition being treated. Some individuals may experience improvement in symptoms within a few weeks, while others may take longer. It is important to continue taking ruxolitinib as prescribed by your healthcare provider.

Ruxolitinib may increase the risk of serious infections, so it is important to contact your healthcare provider if you develop signs of infection such as fever or persistent cough. Additionally, ruxolitinib may affect blood cell counts, so regular blood tests will be required to monitor your condition.

The use of ruxolitinib during pregnancy or breastfeeding is not recommended due to limited data on its safety. It is important to discuss the potential risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.