RUCAPARIB - ORAL

RUCAPARIB - ORAL

PHONETIC PRONUNCIATION: (roo-KAP-a-rib)

COMMON BRAND NAME(S): Rubraca

GENERIC NAME(S): rucaparib camsylate

Uses

USES: This medication is used to treat certain cancers (such as ovarian, fallopian tube, or peritoneal cancer). It works by slowing or stopping the growth of cancer cells.


How to use RUCAPARIB - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking rucaparib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually twice daily (about 12 hours apart). The dosage is based on your medical condition and response to treatment. If you vomit after taking a dose, do not take another dose at that time. Take your next dose at the regular time. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Side Effects

SIDE EFFECTS: Nausea/vomiting, diarrhea, constipation, stomach/abdominal pain, decreased appetite, metallic taste, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk. Tell your doctor right away if you have any serious side effects, including: shortness of breath, tingling/burning/blisters of the hands/feet. This medication decreases bone marrow function, an effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. This medication may also cause certain cancers of the bone marrow (myelodysplastic syndrome, Acute Myeloid Leukemia - AML). Tell your doctor right away if you develop any of the following symptoms: unusual weight loss, unusual tiredness, pale skin, signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising/bleeding. Rucaparib can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking rucaparib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Rucaparib can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using rucaparib. Rucaparib may harm an unborn baby. Your doctor may order a pregnancy test before you start this medication. Ask about reliable forms of birth control while using this medication and for 6 months after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for 2 weeks after stopping treatment is not recommended. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for RUCAPARIB - ORAL

Rucaparib is an oral medication used for the treatment of ovarian cancer. It belongs to a class of drugs called poly (ADP-ribose) polymerase (PARP) inhibitors.

Rucaparib works by inhibiting the PARP enzymes, which play a role in DNA repair. By inhibiting these enzymes, Rucaparib helps prevent cancer cells from repairing their damaged DNA, leading to their death.

Rucaparib is generally prescribed for adult patients with advanced ovarian cancer who have already received at least two chemotherapy regimens. It may also be recommended for patients who have a specific genetic mutation called the BRCA mutation.

Common side effects of Rucaparib may include nausea, fatigue, vomiting, diarrhea, decreased appetite, stomach pain, changes in taste, constipation, and headache. It is important to discuss any side effects with your healthcare provider.

Rucaparib is usually taken orally with or without food. It is important to follow the prescribed dosage and schedule provided by your healthcare provider. Swallow the tablets whole with water and do not crush, chew, or dissolve them.

Rucaparib may have certain precautions and warnings, such as the risk of developing bone marrow problems, potential harm to an unborn baby, and interactions with other medications. It is important to inform your healthcare provider about all your medical conditions, allergies, and medications you are taking.

Rucaparib is not a curative treatment for ovarian cancer but aims to slow down the growth and progression of the disease. It may help extend the time before cancer worsens or reoccurs.

Yes, Rucaparib can be used alone or in combination with other treatments, such as chemotherapy or other targeted therapies. The exact treatment plan will depend on the specific characteristics of the cancer and the individual patient.

The duration of Rucaparib treatment varies depending on the response to the medication and the overall treatment plan determined by your healthcare provider. It is important to continue taking Rucaparib as long as recommended, even if you feel well.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.