ROLAPITANT - ORAL

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ROLAPITANT - ORAL

PHONETIC PRONUNCIATION: (roe-LA-pi-tant)

COMMON BRAND NAME(S): Varubi

GENERIC NAME(S): rolapitant HCl

Uses

USES: Rolapitant is used with other medications to help prevent delayed nausea and vomiting caused by cancer drug treatment (chemotherapy). It works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting.


How to use ROLAPITANT - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually within 2 hours before you receive your chemotherapy. Do not take this medication more often than once every 2 weeks. Tell your doctor if nausea or vomiting occurs.

Side Effects

SIDE EFFECTS: Stomach upset or mouth sores may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using rolapitant, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Rolapitant can slow down the removal of other medications from your body, which may affect how they work. This effect can last 4 weeks or longer after your dose of rolapitant. Examples of affected drugs include dextromethorphan, pimozide, thioridazine, among others. Other medications can affect the removal of rolapitant from your body, which may affect how rolapitant works. Examples include rifamycins (such as rifampin, rifabutin), among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

VARUBI 90 MG TABLET
VARUBI 90 MG TABLET
VARUBI 90 MG TABLET
color
blue
shape
oblong
imprint
T0101, 100

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Faq for ROLAPITANT - ORAL

Rolapitant is an oral medication that belongs to a class of drugs called neurokinin-1 (NK-1) receptor antagonists. It is used in combination with other medications to prevent nausea and vomiting associated with certain cancer treatments, such as chemotherapy.

Rolapitant works by blocking the action of substance P, a neurotransmitter that plays a role in triggering nausea and vomiting. By inhibiting substance P, rolapitant helps to prevent or reduce chemotherapy-induced nausea and vomiting.

Rolapitant is given as a single dose before chemotherapy treatment. It is usually taken orally with or without food. Follow your healthcare provider's instructions regarding the proper dosing schedule and duration of treatment.

Common side effects of rolapitant may include constipation, headache, fatigue, hiccups, and changes in taste perception. Inform your doctor if any side effects persist or worsen.

The safety and effectiveness of rolapitant in pediatric patients have not been established, and it is typically used only in adults.

Yes, several medications can interact with rolapitant. Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, to minimize the risk of interactions.

It is advisable to avoid or limit alcohol consumption while taking rolapitant as alcohol may exacerbate certain side effects, such as dizziness or drowsiness.

The half-life of rolapitant is approximately 180 hours (about 7.5 days). This means it takes about 7.5 days for the body to eliminate half of the medication from the system.

There is limited information on the use of rolapitant during pregnancy or breastfeeding. Consult with your healthcare provider to weigh the potential risks and benefits before using rolapitant in these situations.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.