RITUXIMAB - INJECTION

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RITUXIMAB - INJECTION

PHONETIC PRONUNCIATION: (ri-TUX-i-mab)

COMMON BRAND NAME(S): Rituxan

GENERIC NAME(S): rituximab

Uses

USES: Rituximab is used to treat certain types of cancer (such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia). It works by slowing or stopping the growth of cancer cells. Rituximab is used to treat rheumatoid arthritis and can decrease joint pain and swelling. It is also used to treat certain types of blood vessel disease (such as Wegener's granulomatosis, microscopic polyangiitis) and can decrease the swelling of the blood vessels.


How to use RITUXIMAB - INJECTION

HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using rituximab and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Your doctor should prescribe other medications (such as acetaminophen, an antihistamine, methylprednisolone) for you to take before each treatment to help reduce side effects, such as fever and chills. Carefully follow your doctor's instructions. This medication is given by slow injection into a vein by a health care professional as directed by your doctor. The dosage and treatment schedule are based on your medical condition, body size, and response to treatment.

Side Effects

SIDE EFFECTS: See also Warning section. Nausea, vomiting, headache, dizziness, joint/muscle pain, weakness, or flushing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk. Tell your doctor right away if you have any serious side effects, including: swelling hands/ankles/feet, increased thirst/urination, numbness/tingling of arms/legs. Rituximab sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To lower your risk, your doctor may add a medication and tell you to drink plenty of fluids. Tell your doctor right away if you have symptoms such as: low back/side pain (flank pain), signs of kidney problems (such as painful urination, pink/bloody urine, change in the amount of urine), muscle spasms/weakness. This medication can decrease blood cells, which can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. Tell your doctor right away if you develop any of the following symptoms: easy bleeding/bruising, black/tarry stools, vomit that looks like coffee grounds, signs of an infection (such as sore throat that doesn't go away, fever, chills), unusual tiredness, pale skin. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using rituximab, tell your doctor or pharmacist if you are allergic to it; or to mouse protein; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease, heart problems (such as irregular heartbeat, previous heart attack), bleeding/blood disorders, current/recent infections. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Rituximab can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. Older adults may be at greater risk for heart problems (such as irregular heartbeat) or lung problems while using this drug. During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 1 year after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for at least 6 months after treatment is not recommended. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: other drugs that weaken the immune system/increase the risk of infection (such as tofacitinib, natalizumab, fingolimod).

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for RITUXIMAB - INJECTION

Rituximab is a medication that belongs to a group of drugs called monoclonal antibodies. It is used to treat certain types of cancer like non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and certain autoimmune diseases like rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis.

Rituximab works by targeting and binding to a protein called CD20 found on the surface of certain immune cells called B lymphocytes. By binding to CD20, rituximab helps to destroy these cells, leading to a reduction in tumor growth and immune system activity.

Rituximab is typically administered as an intravenous (IV) infusion by a healthcare professional in a hospital or clinic setting. The dosage and infusion rate will vary depending on the specific condition being treated.

Common side effects of rituximab may include infusion reactions (fever, chills, rash, nausea), infections, fatigue, cough, headache, muscle pain, and low white blood cell count. It is important to report any side effects to your healthcare provider.

Yes, rituximab can cause serious side effects, including severe infusion reactions, progressive multifocal leukoencephalopathy (a rare brain infection), severe infections, heart problems, lung problems, and skin reactions. It is important to seek medical attention immediately if you experience any concerning symptoms.

Rituximab has the potential to harm an unborn baby and may also pass into breast milk, so it is generally not recommended for use during pregnancy or breastfeeding. Discuss with your healthcare provider if you have concerns or are planning a pregnancy.

The response to rituximab treatment varies depending on the specific condition being treated. In some cases, improvement may be seen within a few weeks, while in other cases it may take several months. Your healthcare provider will monitor your progress and adjust the treatment plan accordingly.

Rituximab may interact with certain medications, including live vaccines and other immunosuppressant drugs. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions.

The frequency and duration of rituximab treatment can vary depending on the condition being treated and the individual patient. Some conditions may require multiple treatment cycles, while others may require ongoing maintenance therapy. Your healthcare provider will determine the appropriate treatment plan for you.

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Warning

WARNING: Rituximab may rarely cause serious (sometimes fatal) side effects including severe breathing problems or heart problems (such as heart attack, irregular heartbeat). If these serious side effects occur, they usually happen during the first treatment with rituximab. Your doctor will carefully watch you during treatment and may stop or slow down your treatment if you have any signs of a reaction. Get medical help right away if you have trouble breathing, itching, swelling (especially of the throat/lips), dizziness, fast/slow/irregular heartbeat, or chest pain. Rarely, people using this medication have had serious (sometimes fatal) skin reactions (such as Stevens-Johnson syndrome). Get medical help right away if you develop any rash, blisters, peeling skin, or sores on your skin, lips, or in your mouth. This medication may increase your risk of getting a rare but very serious (possibly fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if you have any of these side effects: clumsiness, loss of coordination/balance, weakness, sudden change in your thinking (such as confusion, difficulty concentrating, memory loss), difficulty talking/walking, seizure, vision changes. Rituximab may cause serious (possibly fatal) liver disease in people who have a current or past infection with hepatitis B. This may occur during treatment or up to 2 years after treatment is finished. Before starting this medication, tell your doctor if you have ever had hepatitis B. Your doctor should order a test to see if you have the hepatitis B infection before starting treatment. Tell your doctor right away if you have symptoms of liver disease, such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, or dark urine.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.