RIFABUTIN - ORAL

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RIFABUTIN - ORAL

PHONETIC PRONUNCIATION: (rye-fuh-BYOU-tin)

COMMON BRAND NAME(S): Mycobutin

GENERIC NAME(S): rifabutin

Uses

USES: This medication is used alone or with another medication to help prevent a certain serious infection (Mycobacterium avium complex-MAC). Rifabutin is known as a rifamycin antibiotic. It works by stopping the growth of bacteria. This antibiotic treats and prevents only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.


How to use RIFABUTIN - ORAL

HOW TO USE: Take this medication by mouth with or without food, usually once or twice daily or as directed by your doctor. Take this medication with food if stomach upset occurs. For the treatment of tuberculosis, this drug is sometimes taken twice weekly. Dosage is based on your medical condition, weight, interacting drugs, and response to treatment. For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early or skipping doses may allow the bacteria to continue to grow, which may result in a return of the infection and cause the infection to be more difficult to treat (resistant). Tell your doctor if your condition persists or worsens.

Side Effects

SIDE EFFECTS: Diarrhea, stomach upset, changes in taste, or nausea/vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This medication may cause urine, sweat, saliva, or tears to turn brown-orange. This effect is harmless and will disappear when the medication is stopped. However, dentures and contact lenses may be permanently stained. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these rare but serious side effects occur: easy bleeding/bruising, signs of a new infection (such as fever, persistent sore throat/cough), muscle weakness/pain, joint pain/swelling, eye pain/redness, vision problems, chest pain/pressure, persistent nausea/vomiting, unusual weakness/tiredness, dark urine, yellowing eyes/skin. This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking rifabutin, tell your doctor or pharmacist if you are allergic to it; or to other rifamycins (such as rifampin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, a certain blood disorder (porphyria). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Rifabutin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding. If you have HIV disease, do not breast-feed because breast milk can transmit HIV.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: azole antifungals (such as fluconazole, itraconazole, voriconazole), ciprofloxacin, delavirdine, macrolide antibiotics (such as clarithromycin). Rifabutin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aprepitant/fosaprepitant, lurasidone, phenytoin, ranolazine, suvorexant, tacrolimus, tasimelteon, "blood thinners" (such as warfarin), calcium channel blockers (such as diltiazem, verapamil), certain combination products used to treat chronic hepatitis C (ombitasvir/paritaprevir/ritonavir), among others. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

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MYCOBUTIN 150 MG CAPSULE
MYCOBUTIN 150 MG CAPSULE
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MYCOBUTIN, PHARMACIA & UPJOHN
MYCOBUTIN 150 MG CAPSULE
MYCOBUTIN 150 MG CAPSULE
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MYCOBUTIN 150 MG CAPSULE
MYCOBUTIN 150 MG CAPSULE
MYCOBUTIN 150 MG CAPSULE
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red-brown
shape
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MYCOBUTIN, PHARMACIA & UPJOHN
MYCOBUTIN 150 MG CAPSULE
MYCOBUTIN 150 MG CAPSULE
MYCOBUTIN 150 MG CAPSULE
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shape
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MYCOBUTIN, PHARMACIA & UPJOHN
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
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MYCOBUTIN, PHARMACIA & UPJOHN
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
color
red brown
shape
oblong
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LU, R01
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
color
red brown
shape
oblong
imprint
LU, R01
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
RIFABUTIN 150 MG CAPSULE
color
red brown
shape
oblong
imprint
LU, R01

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Faq for RIFABUTIN - ORAL

Rifabutin is an oral medication used to prevent and treat certain bacterial infections, including tuberculosis (TB) and Mycobacterium avium complex (MAC) in people with a weakened immune system, such as those with HIV/AIDS.

Rifabutin belongs to the class of antibiotics called rifamycins. It works by inhibiting the growth and replication of bacteria, specifically by blocking the activity of an enzyme called RNA polymerase, which is essential for bacterial DNA synthesis.

Rifabutin is usually taken once daily with a full glass of water, either with or without food. It is important to follow the prescribed dosage and duration of treatment recommended by your doctor.

Common side effects of rifabutin may include nausea, vomiting, stomach pain, diarrhea, difficulty sleeping, headache, dizziness, or rash. It is important to inform your doctor if these side effects become severe or persistent.

Yes, rifabutin can interact with several medications, including HIV protease inhibitors, certain antifungal drugs, corticosteroids, blood thinners, and others. It is crucial to inform your doctor or pharmacist about all the medications you are currently taking to avoid potential drug interactions.

The duration of rifabutin treatment depends on the specific condition being treated. For tuberculosis, treatment typically lasts for several months, while treatment for MAC infection may require lifelong therapy. It is important to complete the full course of treatment as prescribed by your doctor.

Rifabutin should only be used during pregnancy if the potential benefits outweigh the risks. It can pass into breast milk, so it is important to consult with your doctor before taking rifabutin while breastfeeding.

If you miss a dose of rifabutin, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Although rare, rifabutin can cause serious side effects such as severe allergic reactions, liver problems, anemia, or changes in vision. If you experience any unusual or severe symptoms while taking rifabutin, seek immediate medical attention.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.