POSACONAZOLE DELAYED-RELEASE - ORAL

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POSACONAZOLE DELAYED-RELEASE - ORAL

PHONETIC PRONUNCIATION: (POE-sa-KON-a-zole)

COMMON BRAND NAME(S): Noxafil

GENERIC NAME(S): posaconazole

Uses

USES: Posaconazole is used to prevent certain fungal infections in patients who have severely weakened immune systems (such as patients who have had chemotherapy). It belongs to a class of drugs known as azole antifungals. It works by stopping the growth of fungi.


How to use POSACONAZOLE DELAYED-RELEASE - ORAL

HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start taking posaconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily with food. Do not crush or chew delayed-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. The length of treatment is based on your medical condition. This medication works best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. The tablet and suspension forms of posaconazole may deliver different amounts of medication. Do not switch between the different forms of this medication without your doctor's permission and directions. Tell your doctor if you have severe diarrhea or vomiting. Posaconazole may not work as well.

Side Effects

SIDE EFFECTS: Nausea, vomiting, diarrhea, headache, abdominal pain, dizziness, trouble sleeping, or stomach upset may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: unusual tiredness, easy bruising/bleeding, weakness, muscle cramps, mental/mood changes, swelling of the ankles/feet, signs of infection (such as chills, fever), vaginal bleeding, shortness of breath, increased thirst/urination. Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, severe dizziness, fainting. Posaconazole has rarely caused very serious (possibly fatal) liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: yellowing eyes/skin, dark urine, persistent nausea/vomiting, severe stomach/abdominal pain. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Posaconazole can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, get medical help right away if you develop any rash. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking posaconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (such as ketoconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease. Posaconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using posaconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using posaconazole safely. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana. Alcohol may also increase the risk of serious liver problems. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of posaconazole from your body, which may affect how posaconazole works. Examples include efavirenz, rifamycins (such as rifabutin), certain drugs used to treat seizures (such as phenytoin), among others. This drug can slow down the removal of other drugs from your body, which may affect how they work. Examples of affected drugs include certain alpha blockers (such as alfuzosin, silodosin, tamsulosin), certain benzodiazepines (such as midazolam), dronedarone, ergot alkaloids (such as ergotamine, dihydroergotamine), pimozide, quinidine, rivaroxaban, sirolimus, certain "statin" drugs (such as atorvastatin, lovastatin, simvastatin), among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

NOXAFIL DR 100 MG TABLET
NOXAFIL DR 100 MG TABLET
NOXAFIL DR 100 MG TABLET
color
yellow
shape
oblong
imprint
100

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Faq for POSACONAZOLE DELAYED-RELEASE - ORAL

Posaconazole delayed-release oral medication is used to prevent and treat certain fungal infections, such as aspergillosis and candidiasis, in individuals with a weakened immune system.

It is important to follow the instructions given by your healthcare provider. Generally, posaconazole delayed-release oral medication is taken with a full meal and should be swallowed whole without crushing, chewing, or breaking the tablet.

Common side effects may include nausea, diarrhea, headache, fatigue, and abnormal liver function tests. It is important to contact your healthcare provider if you experience severe side effects such as allergic reactions, persistent vomiting or diarrhea, jaundice, or signs of a new infection.

Yes, posaconazole delayed-release oral medication can interact with various medications, including certain antiviral drugs, antibiotics, antifungal medications, and medications that affect the liver. It is crucial to inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.

The duration of treatment with posaconazole delayed-release oral medication will be determined by your healthcare provider based on the specific fungal infection being treated and your response to the medication. It is important to follow your prescribed treatment plan and not stop taking the medication without consulting your healthcare provider.

It is generally recommended to avoid consuming alcohol while taking posaconazole delayed-release oral medication, as alcohol may increase the risk of certain side effects and decrease the effectiveness of the medication. It is best to consult your healthcare provider for specific guidance based on your individual circumstances.

Posaconazole delayed-release is a medication used to treat certain fungal infections in people with weakened immune systems. It belongs to a class of drugs called azole antifungals.

Posaconazole works by preventing the growth of various types of fungi. It inhibits the synthesis of ergosterol, a crucial component of fungal cell membranes, which ultimately disrupts their growth and reproduction.

Common side effects may include nausea, diarrhea, vomiting, headache, stomach pain, and dizziness. It is important to inform your doctor if you experience any severe or persistent side effects.

You should take posaconazole delayed-release with a full meal or a nutritional supplement. It is usually taken twice daily or as directed by your healthcare provider. Follow the dosage instructions carefully and complete the full course of treatment.

It is important to inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Certain medications can interact with posaconazole, potentially affecting its effectiveness or causing side effects.

Posaconazole delayed-release may harm an unborn baby and should not be used during pregnancy unless clearly needed. It is not recommended for use while breastfeeding as it can pass into breast milk and may harm the nursing baby. Consult your healthcare provider for personalized advice.

It is generally recommended to avoid alcohol while taking posaconazole delayed-release, as alcohol can increase the risk of potential side effects and may hamper the effectiveness of the medication. It is best to consult your doctor regarding alcohol consumption during treatment.

If you miss a dose, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

The time it takes for posaconazole to show its effects can vary depending on the individual and the specific infection being treated. It is important to complete the full course of treatment, even if you start feeling better before finishing.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.