PLERIXAFOR - INJECTION

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PLERIXAFOR - INJECTION

PHONETIC PRONUNCIATION: (pler-IX-a-for)

COMMON BRAND NAME(S): Mozobil

GENERIC NAME(S): plerixafor

Uses

USES: Plerixafor is used by patients with certain types of cancer (non-Hodgkin's lymphoma-NHL, multiple myeloma-MM) to prepare them for stem cell transplant. Stem cells, which are found mainly in the bone marrow, turn into red blood cells, white blood cells, and platelets. Plerixafor is used to help stem cells move from the bone marrow to the bloodstream so that the cells can be collected and stored. The stem cells are then infused back into the patient after chemotherapy or radiation.


How to use PLERIXAFOR - INJECTION

HOW TO USE: Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Inject this medication under the skin as directed by your doctor, usually about 11 hours before the blood filtering procedure. The dosage is based on your medical condition and weight. Your doctor will also direct you to use another medication (G-CSF) to prepare for the procedure. Carefully follow your doctor's instructions on how to use both medications correctly.

Side Effects

SIDE EFFECTS: Diarrhea, nausea, vomiting, gas, dizziness, or pain/redness/swelling at injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: left upper abdominal pain, left shoulder pain, fainting, easy bleeding/bruising. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using plerixafor, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, leukemia. This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using plerixafor. Plerixafor may harm an unborn baby. Your doctor should order a pregnancy test before you start this medication. Ask about reliable forms of birth control while using this medication and for one week after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using this drug and for one week after stopping treatment. Consult your doctor before breast-feeding.

Interactions

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, severe dizziness.

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MOZOBIL 24 MG/1.2 ML VIAL
MOZOBIL 24 MG/1.2 ML VIAL
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Faq for PLERIXAFOR - INJECTION

Plerixafor injection is used in combination with other medications to help increase the number of hematopoietic stem cells in the blood for autologous stem cell transplant in patients with multiple myeloma or non-Hodgkin lymphoma.

Plerixafor works by blocking a protein called CXCR4, which helps stem cells stay in the bone marrow. By blocking CXCR4, plerixafor allows stem cells to be released into the bloodstream, making them available for collection for transplant.

Plerixafor is given as an injection under the skin (subcutaneously) about 11 hours before the scheduled stem cell collection. The exact dosage and timing will be determined by your healthcare provider.

The most common side effects of plerixafor injection include diarrhea, nausea, vomiting, injection site reactions (redness, swelling, pain), fatigue, dizziness, headache, and decreased white blood cell count. It is essential to inform your doctor about any bothersome or severe side effects.

Plerixafor can interfere with the effectiveness of certain medications, including G-CSF, St. John's wort, and drugs that affect liver enzymes. It is crucial to inform your healthcare provider about all the medications you are taking before starting plerixafor.

Plerixafor is classified as a pregnancy category D drug, indicating a potential risk to the fetus. It should only be used if the potential benefits outweigh the potential risks. It is essential to discuss the risks and benefits with your doctor if you are pregnant or planning to become pregnant.

It is unknown whether plerixafor passes into breast milk. Due to the lack of data, it is recommended to avoid breastfeeding while on plerixafor.

Plerixafor vials should be stored at controlled room temperature between 20°C to 25°C (68°F to 77°F). They should be protected from light and kept out of reach of children.

If you miss a dose of plerixafor, consult your healthcare provider immediately. They will provide guidance on whether the dose can be rescheduled or if any adjustments need to be made.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.