PEGLOTICASE - INJECTION
PHONETIC PRONUNCIATION: (peg-LOE-ti-kase)
COMMON BRAND NAME(S): Krystexxa
GENERIC NAME(S): pegloticase
Uses
USES: Pegloticase is used to treat gout which has not responded to the usual treatments. It works by lowering high levels of uric acid in your body. Increased uric acid in your body can cause gout.
How to use PEGLOTICASE - INJECTION
HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using pegloticase and each time you get a refill. If you have any questions, ask your doctor or pharmacist. If you are taking other medications (such as allopurinol, febuxostat) by mouth to lower the level of uric acid in your body, your doctor will direct you to stop the medication before starting and during treatment with pegloticase. Taking these drugs with pegloticase may lessen how well it works. This medication is given by injection into a vein (over at least 2 hours) by a healthcare professional. It is usually given every 2 weeks. Use this medication regularly in order to get the most benefit from it. Remember to receive it every 2 weeks. It may help to mark your calendar with a reminder. You may experience more gout attacks for several months after starting this medicine while your body removes extra uric acid. Your doctor may prescribe additional medication (such as colchicine, nonsteroidal anti-inflammatory drugs-NSAIDs) to help prevent and treat these gout attacks. Tell your doctor if your condition persists or worsens.
Side Effects
Precautions
Interactions
Overdose
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Faq for PEGLOTICASE - INJECTION
Pegloticase injection is used to treat chronic gout in adults.
Pegloticase works by breaking down uric acid in the body, which helps to reduce the symptoms of chronic gout.
Pegloticase is administered as a once every two-week infusion.
Common side effects of Pegloticase injection include gout flare-ups, infusion reactions, allergic reactions, and congestive heart failure.
If you miss a dose of Pegloticase, contact your healthcare provider to reschedule the infusion as soon as possible.
No, Pegloticase injection should only be administered by a healthcare professional in a clinical setting.
Pegloticase injection may start reducing symptoms of chronic gout within a few days of the first infusion.
You should not stop any other prescribed gout medications without consulting your healthcare provider.
No, Pegloticase is not approved for use in children or adolescents.
Warning
WARNING: Pegloticase may rarely cause a serious allergic reaction. This may occur during or after the infusion of the medication. Your doctor will check your blood before each treatment and monitor you closely during and after infusion. Your doctor should prescribe other medications (such as antihistamines, corticosteroids) to help prevent an allergic reaction. However, serious allergic reactions may still occur in a few patients. Get medical help right away if you develop any signs of an allergic reaction, such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, chest discomfort/pain. Do not use this medication if you have a certain metabolic disorder called glucose-6-phosphate dehydrogenase (G6PD) deficiency because it can severely damage your red blood cells leading to anemia (hemolysis). If you are of African, Mediterranean, or Southern Asian descent, you may be at higher risk for G6PD deficiency and should be tested to see if you have this condition before starting this medication.
Disclaimer
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
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