PEGADEMASE - INJECTION

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PEGADEMASE - INJECTION

PHONETIC PRONUNCIATION: (peg-AD-e-mase)

COMMON BRAND NAME(S): Adagen

GENERIC NAME(S): pegademase bovine

Uses

USES: Pegademase is used to treat a certain rare genetic immune system problem (severe combined immune deficiency disease-SCID). Pegademase replaces a certain natural substance (an enzyme called adenosine deaminase-ADA) that is missing in people with SCID. This medication increases the number of blood cells that prevent and fight infection (lymphocytes) by helping the body get rid of certain substances that kill lymphocytes. This medication does not help immune system problems due to other causes (such as AIDS, bone marrow depression).


How to use PEGADEMASE - INJECTION

HOW TO USE: See also Precautions and Notes sections. This medication is given by injection into a muscle as directed by your doctor, usually once a week. Do not inject into a vein. The dosage is based on your medical condition, weight, and response to treatment. Use this medication on schedule so it will work well. Your doctor will order blood tests often to see how it is working for you and find the best dose for you. Keep all medical/lab appointments. If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. This product should be clear and colorless. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely. Your immune system will usually improve slowly, and you should have fewer/less severe infections in 2 to 6 months.

Side Effects

SIDE EFFECTS: Bleeding/bruising/pain at the injection site and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using pegademase, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clotting problems (such as hemophilia, low blood platelets). This medication may take several weeks or months to work. Even after the medication begins to work, you may still be at increased risk for infection. Ask your doctor how to prevent infection. Wash your hands well, and stay away from people who have an infection. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. One product that may interact with this drug is: vidarabine.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for PEGADEMASE - INJECTION

PEGADEMASE Injection is used for the treatment of patients with adenosine deaminase severe combined immune deficiency (ADA-SCID).

PEGADEMASE Injection works by replacing the deficient or absent adenosine deaminase (ADA) enzyme, which is responsible for the breakdown of toxic substances in the body. This helps restore immune function in patients with ADA-SCID.

PEGADEMASE Injection is administered as a subcutaneous (under the skin) injection. The injection site should be rotated to avoid repeated injection at the same location.

The most commonly reported side effects of PEGADEMASE Injection include injection site reactions, fever, vomiting, headache, nausea, and diarrhea. It is important to discuss any side effects with your healthcare provider.

The dosage of PEGADEMASE Injection may vary depending on the age, weight, and overall health of the patient. It is important to follow the dosage instructions provided by your healthcare provider.

The safety of PEGADEMASE Injection during pregnancy or breastfeeding has not been established. It is recommended to consult with your healthcare provider before using PEGADEMASE Injection in these situations.

Currently, there is no generic version of PEGADEMASE Injection available. It is only available as a brand-name medication.

The duration of treatment with PEGADEMASE Injection may vary depending on the individual patient and their response to the medication. It is important to follow the treatment plan recommended by your healthcare provider.

PEGADEMASE Injection is approved for use in both pediatric and adult patients with adenosine deaminase severe combined immune deficiency (ADA-SCID).

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.