NIRAPARIB - ORAL

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NIRAPARIB - ORAL

PHONETIC PRONUNCIATION: (nye-RAP-a-rib)

COMMON BRAND NAME(S): Zejula

GENERIC NAME(S): niraparib tosylate

Uses

USES: Niraparib is used to treat ovarian cancer, fallopian tube cancer, or a type of cancer of the abdomen (primary peritoneal cancer). It works by slowing the growth of cancer cells.


How to use NIRAPARIB - ORAL

HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start taking niraparib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once daily. Swallow the capsules whole. The dosage is based on your medical condition and response to treatment. If you vomit after taking a dose, do not take another dose at that time. Take your next dose at the regular time. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Side Effects

SIDE EFFECTS: Nausea, vomiting, loss of appetite, constipation, bad taste in your mouth, dry mouth, mouth sores, dizziness, headache, or trouble sleeping may occur. Rarely, nausea and vomiting can be severe. Taking this medication at bedtime may help reduce nausea. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals or limiting activity may help lessen nausea and vomiting. If any of these effects last or get worse, tell your doctor or pharmacist promptly. People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk. This medication decreases bone marrow function, an effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. Rarely, this medication may also cause certain cancers of the bone marrow or blood cells. Your doctor will monitor your blood cell count. Tell your doctor right away if you develop any of the following symptoms: signs of anemia (such as unusual tiredness, pale skin, shortness of breath, fast heartbeat), signs of infection (such as sore throat that doesn't go away, fever, chills, cough), easy bruising/bleeding (such as pink/bloody urine, black/bloody stools), weakness, weight loss. This medication may raise your blood pressure and heart rate. Sometimes these effects can be serious. Check your blood pressure and heart rate regularly and tell your doctor if the results are high. Your doctor may control your blood pressure and heart rate with medication. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking niraparib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (such as chest pain, irregular heartbeat), high blood pressure. Niraparib can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medication is not recommended for use during pregnancy. It may harm an unborn baby. Your doctor may order a pregnancy test before you start this medication. Discuss reliable forms of birth control (such as condoms, birth control pills) with your doctor, for use during treatment and for 6 months after the last dose of niraparib. If you become pregnant or think you may be pregnant, tell your doctor right away. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended during treatment and for 1 month after the last dose. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

ZEJULA 100 MG CAPSULE
ZEJULA 100 MG CAPSULE
color
white
shape
oblong
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Niraparib, 100 mg

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Faq for NIRAPARIB - ORAL

Niraparib is an oral medication used for the treatment of certain types of ovarian, fallopian tube, or primary peritoneal cancer in adult patients. It belongs to the class of drugs called PARP inhibitors.

Niraparib works by blocking the activity of an enzyme called poly (ADP-ribose) polymerase (PARP), which is involved in repairing damaged DNA in cells. By inhibiting PARP, niraparib helps prevent cancer cells from repairing their DNA, leading to their death.

Niraparib is used as maintenance therapy for adults with advanced ovarian, fallopian tube, or primary peritoneal cancer who have responded to initial platinum-based chemotherapy. It is used to help prolong the progression-free survival of these patients.

Niraparib is taken orally, usually once a day, with or without food. The dosage and duration of treatment will be determined by your healthcare provider based on your specific condition.

Common side effects of niraparib may include nausea, vomiting, fatigue, constipation, anemia, loss of appetite, abdominal pain, diarrhea, and headache. It is important to inform your doctor about any side effects you experience.

Yes, niraparib can cause serious side effects such as bone marrow suppression, which may lead to low blood cell counts, including low red blood cells (anemia), low white blood cells (neutropenia), and low platelets (thrombocytopenia). These can increase the risk of infections, bleeding, and fatigue. Inform your doctor immediately if you experience any unusual symptoms.

No, niraparib is specifically indicated for adult patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer who have responded to initial platinum-based chemotherapy. Its use should be based on the results of specific tests and consultation with a healthcare professional.

It is important to inform your healthcare provider about all medications, including over-the-counter and herbal supplements, that you are taking while on niraparib. Some medications may interact with niraparib and affect its effectiveness or increase the risk of side effects.

Niraparib is not recommended during pregnancy, as it may harm the developing fetus. It is also not recommended while breastfeeding, as it can pass into breast milk and harm the infant. Discuss with your doctor the potential risks and benefits before starting niraparib if you are pregnant or breastfeeding.

Niraparib is an oral medication commonly used to treat advanced ovarian cancer. It belongs to a class of drugs known as poly(ADP-ribose) polymerase (PARP) inhibitors. Niraparib works by blocking an enzyme called PARP, which helps cancer cells repair their DNA. By inhibiting PARP, Niraparib prevents cancer cells from repairing DNA damage, leading to their death.

Niraparib is primarily used in the treatment of recurrent ovarian cancer that has responded to platinum-based chemotherapy. It is specifically approved for patients with germline or somatic BRCA-mutated cancers. However, it may also be considered for other patients with advanced ovarian cancer, based on their individual circumstances.

The most common side effects associated with Niraparib include nausea, fatigue, constipation, vomiting, abdominal pain, anemia, low platelet count, diarrhea, and decreased appetite. Patients should inform their healthcare providers about any side effects experienced.

Niraparib is typically taken orally once daily, with or without food. The dose and duration of treatment may vary depending on individual patient factors. It is essential to follow the prescribed dosage and schedule given by your healthcare provider.

Niraparib can interact with certain medications, including strong CYP3A inhibitors and strong CYP3A inducers. These interactions can affect the metabolism and effectiveness of Niraparib. It is crucial to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Niraparib.

Niraparib may harm the fetus if used during pregnancy, and it is recommended to avoid pregnancy while taking it. It is also not recommended to breastfeed while using Niraparib, as it may pass into breast milk. Consult with your healthcare provider for suitable birth control methods and further guidance.

If you miss a dose of Niraparib, take it as soon as you remember, unless it is close to the next scheduled dose. Do not take two doses at once to make up for the missed dose. Consult your healthcare provider for further instructions.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.