MESNA - INJECTION

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MESNA - INJECTION

PHONETIC PRONUNCIATION: (MES-na)

COMMON BRAND NAME(S): Mesnex

GENERIC NAME(S): mesna

Uses

USES: This medication is used to reduce the risk of bleeding in the bladder (hemorrhagic cystitis), which is a very serious side effect of treatment with a cancer chemotherapy drug called ifosfamide. Mesna helps to protect the lining of the bladder against damage from ifosfamide. The body breaks down ifosfamide to form a product that can harm the bladder, and mesna works by making this product less harmful. However, mesna does not change ifosfamide's anti-cancer effects.


How to use MESNA - INJECTION

HOW TO USE: This medication is given by injection into a vein by a health care professional. Dosage is based on your body size and your dose of ifosfamide (or cyclophosphamide). While using this medication, drink at least a quart (4 cups or 1 liter) of liquid each day unless directed otherwise by your doctor. Doing so will also help to reduce the bladder side effects from ifosfamide. Mesna is very effective in reducing the risk of hemorrhagic cystitis in most patients. However, it may not work in a small number of patients. Therefore, tell your doctor right away if you notice that your urine is pink, red, or bloody.

Side Effects

SIDE EFFECTS: Headache, redness/pain/swelling at the injection site, flushing, dizziness, drowsiness, nausea, vomiting, loss of appetite, diarrhea, constipation, sensitive skin, or flu-like symptoms (such as sore throat, cough, body aches) may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: fast heartbeat, swelling ankles/feet, muscle weakness. Get medical help right away if you have any very serious side effects, including: chest pain. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using mesna, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as benzyl alcohol found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: overactive immune system diseases (autoimmune disorders) that may increase your risk for a mesna allergy (e.g., rheumatoid arthritis, lupus, nephritis). This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Kidney function declines as you grow older. This medication is removed by the kidneys. The elderly may be more sensitive to the effects of this drug. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Since this medication is given with a cancer chemotherapy drug, breast-feeding while using mesna is not recommended. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication may interfere with a certain laboratory test (for urinary ketones), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

MESNEX 1 GRAM/10 ML VIAL
MESNEX 1 GRAM/10 ML VIAL
MESNEX 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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MESNA 1 GRAM/10 ML VIAL
MESNA 1 GRAM/10 ML VIAL
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Faq for MESNA - INJECTION

Mesna injection is used to prevent or reduce the harmful effects of certain chemotherapy medications on the bladder, particularly ifosfamide or cyclophosphamide.

Mesna works by detoxifying a harmful metabolite produced by the chemotherapy drugs, thereby protecting the bladder from damage.

Mesna injection is administered intravenously (IV) or through a central venous catheter, usually before or after the chemotherapy infusion.

The dosage of Mesna injection depends on the chemotherapy regimen being used, but it is typically given at a dose of 20% to 33% of the total ifosfamide or cyclophosphamide dose.

Common side effects of Mesna injection include nausea, vomiting, headache, drowsiness, diarrhea, and skin rash. It may also cause a temporary reduction in blood cell counts.

Mesna injection should be used during pregnancy only if clearly needed, as there are limited studies on its safety. It is not known whether Mesna passes into breast milk, so it is recommended to consult with a healthcare professional before breastfeeding while using Mesna.

There are no known major drug interactions with Mesna injection, but it is always essential to inform your healthcare provider about any medications you are taking, including over-the-counter drugs and supplements.

The protective effect of Mesna injection on the bladder usually lasts for about 4 to 8 hours. Multiple doses may be necessary depending on the chemotherapy regimen.

While Mesna injection is highly effective in reducing the risk of bladder damage, it may not completely prevent it. Some patients may still experience mild to moderate bladder irritation or bleeding.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.