SIDE EFFECTS: Nausea, stomach cramping/bloating, dizziness, headache, tiredness, breast tenderness, decrease in breast size, acne, hair loss, weight gain, change in vaginal discharge, or irritation/pain at injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Women using this medication may have irregular menstrual periods or heavier or lighter flow. You may also have some spotting between periods. Your periods may stop completely after you have been receiving this medication for about a year. If this occurs, your periods will normally return after you stop receiving this medication. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression), swelling of the ankles/feet, bone pain, unusual breast discharge, lump in breast, abnormal severe/persistent vaginal bleeding, seizures, persistent nausea/vomiting, severe stomach/abdominal/pelvic pain, unusual weakness/tiredness, dark urine, yellowing skin/eyes. This drug may rarely cause blood clots. Get medical help right away if you notice any of the following rare but very serious side effects: chest/jaw/left arm pain, sudden shortness of breath, coughing up blood, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, tingling/weakness/numbness in the arms/legs, confusion, sudden/severe headache, slurred speech, vision changes/problems (such as double vision, partial or complete vision loss, bulging eyes), weakness on one side of the body. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using medroxyprogesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: stroke or other blood clots (such as in the legs, eyes, lungs), personal/family history of breast cancer, abnormal breast exam, cancer of the cervix, abnormal/unexplained vaginal bleeding, liver disease, depression, frequent use of alcohol/tobacco, asthma, diabetes, heart disease (such as chest pain, heart failure, high blood pressure), kidney disease, migraine, seizures, personal/family history of bone disease (such as osteoporosis). Before having surgery, tell your doctor or dentist about all of the products you use (including prescription drugs, nonprescription drug, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some of the products that may interact with this drug include: acitretin, aminoglutethimide, corticosteroids (such as hydrocortisone, prednisone), isotretinoin, phenytoin, warfarin. Other medications can affect the removal of medroxyprogesterone from your body, which may affect how medroxyprogesterone works. Examples include aprepitant, bexarotene, bosentan, griseofulvin, HIV protease inhibitors (such as atazanavir, nelfinavir, ritonavir), other HIV medications (efavirenz, nevirapine), rifamycins (such as rifampin), many seizure medications (such as barbiturates, carbamazepine, rufinamide, topiramate), St. John's wort, among others. This medication may interfere with certain laboratory tests (including certain hormone levels, thyroid tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you are using this medication.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.