LINAGLIPTIN/METFORMIN - ORAL

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LINAGLIPTIN/METFORMIN - ORAL

PHONETIC PRONUNCIATION: (LIN-a-GLIP-tin/met-FOR-min)

COMMON BRAND NAME(S): Jentadueto

GENERIC NAME(S): linagliptin/metformin HCl

Uses

USES: Linagliptin/metformin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This product contains 2 medications: linagliptin and metformin. Linagliptin works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.


How to use LINAGLIPTIN/METFORMIN - ORAL

HOW TO USE: Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking linagliptin/metformin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually twice daily with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended. Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low).

Side Effects

SIDE EFFECTS: See also Warning section. Nausea, vomiting, stomach upset, diarrhea, or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: joint pain, unusual skin blisters, signs of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain). Get medical help right away if you have any very serious side effects, including: signs of disease of the pancreas (such as persistent nausea/vomiting, severe stomach/abdominal pain which may spread to the back). This medication does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications, or if you do not consume enough calories from food, or if you do unusually heavy exercise. Talk with your doctor or pharmacist about whether the dose of your other diabetes medication(s) needs to be lowered. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: See also Warning section. Before taking this medication, tell your doctor or pharmacist if you are allergic to linagliptin or metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, severe breathing problems (such as obstructive lung disease, severe asthma), liver disease, a disease of the pancreas (pancreatitis), stones in your gallbladder (gallstones). Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop this medication for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure. You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcohol while taking this medication because it can increase your risk of developing lactic acidosis, pancreatitis, and low blood sugar. High fever, "water pills" (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise. It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing. Older adults may be more sensitive to the side effects of this drug, especially low blood sugar or lactic acidosis. Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin). Metformin passes into breast milk. It is unknown if linagliptin passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs. Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet. Other medications can affect the removal of linagliptin from your body, which may affect how linagliptin works. One example is rifampin, among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Overdose can cause lactic acidosis. Symptoms of overdose may include: severe drowsiness, severe nausea/vomiting/diarrhea, rapid breathing, slow/irregular heartbeat.

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Faq for LINAGLIPTIN/METFORMIN - ORAL

Linagliptin/metformin is an oral medication that combines two different drugs, linagliptin and metformin, to help control blood sugar levels in people with type 2 diabetes. Linagliptin belongs to a class of drugs called DPP-4 inhibitors, which help regulate blood sugar levels by increasing the release of insulin and decreasing the production of glucose by the liver. Metformin is a biguanide drug that lowers blood sugar levels by reducing the amount of glucose produced in the liver and improving the body's response to insulin.

Linagliptin/metformin is used to manage blood sugar levels in people with type 2 diabetes. It is typically prescribed as part of a comprehensive treatment plan that includes a healthy diet and regular exercise. It is not intended for the treatment of type 1 diabetes.

Common side effects of linagliptin/metformin may include diarrhea, stomach upset, nausea, vomiting, metallic taste in the mouth, headache, dizziness, or weakness. These side effects usually subside over time. However, if they persist or worsen, it is important to notify your healthcare provider.

Patients with kidney problems, liver disease, heart failure, or a history of lactic acidosis should exercise caution while taking linagliptin/metformin. It is important to inform your doctor about any medical conditions or medications you are currently taking before starting this medication. Additionally, linagliptin/metformin may cause low blood sugar levels (hypoglycemia), so it is important to monitor your blood sugar regularly and be aware of the signs and symptoms of hypoglycemia.

Linagliptin/metformin is typically taken with meals to reduce gastrointestinal side effects. The dosing will be determined by your healthcare provider based on your individual needs and response to the medication. It is important to take the medication as directed and not to exceed the recommended dosage.

Linagliptin/metformin may interact with certain medications, so it is important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and herbal supplements. Some medications may increase the risk of lactic acidosis, a serious condition that can occur with the use of metformin, so it is important to discuss your medication list with your doctor.

Linagliptin/metformin may start working within a few days to a week of starting the medication. However, it may take several weeks to see the full effects on blood sugar control. It is important to continue taking the medication as prescribed and regularly monitor your blood sugar levels.

It is important to consult with your healthcare provider before taking linagliptin/metformin if you are pregnant or planning to become pregnant. This medication is not recommended during breastfeeding as it is unknown if it passes into breast milk.

Linagliptin/metformin should not be stopped suddenly without consulting a healthcare provider. Abruptly discontinuing the medication may cause a sudden increase in blood sugar levels. It is essential to discuss any changes in medication regimen with your doctor.

LINAGLIPTIN/METFORMIN - ORAL Pricing Page Get Discount Coupon

Warning

WARNING: Rarely, too much metformin can build up in the body and cause a serious (sometimes fatal) condition called lactic acidosis. Lactic acidosis is more likely if you are an older adult, if you have kidney or liver disease, dehydration, heart failure, heavy alcohol use, if you have surgery, if you have X-ray or scanning procedures that use iodinated contrast, or if you are using certain drugs. For some conditions, your doctor may tell you to stop taking this medication for a short time. Ask your doctor or pharmacist for more details. Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosis, such as unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.