LETERMOVIR - INJECTION

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LETERMOVIR - INJECTION

PHONETIC PRONUNCIATION: (le-TERM-oh-vir)

COMMON BRAND NAME(S): Prevymis

GENERIC NAME(S): letermovir

Uses

USES: This medication is used to prevent disease caused by a virus called cytomegalovirus (CMV) in people who have received a bone marrow transplant. CMV disease can lead to serious infections in the body, including an infection in the eye, called CMV retinitis, that can cause blindness. Letermovir is an anti-viral drug. It works by stopping the growth of the virus.


How to use LETERMOVIR - INJECTION

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using letermovir and each time you get a refill. If you have any questions, ask your doctor or pharmacist. This medication is given by injection into a vein, as directed by your doctor, usually once a day over 1 hour. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard needles and medical supplies safely. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). For the best effect, use this medication at evenly spaced times. To help you remember, use this medication at the same time every day. Continue to use this medication until the full prescribed amount is finished. Stopping the medication too early may result in an infection.

Side Effects

SIDE EFFECTS: Nausea, diarrhea, vomiting, swelling ankles/feet, cough, or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: fast/irregular heartbeat, signs of kidney problems (such as change in the amount of urine). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using letermovir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include ergot alkaloids (such as ergotamine, dihydroergotamine), flibanserin, pimozide, certain statin drugs (such as pitavastatin, simvastatin), among others. Other medications can affect the removal of letermovir from your body, which may affect how letermovir works. Examples include rifampin, among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for LETERMOVIR - INJECTION

Letermovir is a medication that belongs to a group of drugs known as antiviral agents. It is used to prevent cytomegalovirus (CMV) infection and disease in adults who have received a hematopoietic stem cell transplant.

Letermovir works by inhibiting the replication of CMV. It specifically targets the viral terminase complex, which is involved in the maturation of the CMV virus. By inhibiting this process, Letermovir prevents the production of infectious CMV particles.

Letermovir is administered as an injection into a vein (intravenous) by a healthcare professional. The recommended dosage and treatment duration depend on various factors, including the patient's body weight and transplant type.

The common side effects of Letermovir include nausea, diarrhea, vomiting, peripheral edema, cough, headache, and fatigue. It is always important to discuss any side effects with your healthcare provider.

Yes, Letermovir can interact with other medications. It is crucial to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Letermovir. Some medications, such as cyclosporine and certain antifungals, may interact with Letermovir and affect its effectiveness or increase the risk of side effects.

Letermovir is not recommended for individuals who are allergic to Letermovir or any of its components. It is also contraindicated in pregnant or breastfeeding women, as its safety during these conditions has not been established.

The duration of Letermovir treatment varies depending on the specific patient's situation. Your healthcare provider will determine the appropriate treatment duration, which is typically started shortly before the stem cell transplant and continued for a certain period post-transplant.

If you miss a dose of Letermovir, contact your healthcare provider as soon as possible. They will provide guidance on whether the missed dose should be taken or if any adjustments need to be made to your treatment plan.

Letermovir is not a cure for CMV infection. It is used as a preventive measure to reduce the risk of CMV infection and disease in adult patients who have undergone a hematopoietic stem cell transplant. It is important to follow all prescribed treatments and precautions to manage CMV effectively.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.