LESINURAD - ORAL

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LESINURAD - ORAL

PHONETIC PRONUNCIATION: (le-SIN-ure-ad)

COMMON BRAND NAME(S): Zurampic

GENERIC NAME(S): lesinurad

Uses

USES: Lesinurad is used with another medication (such as allopurinol, febuxostat) to lower uric acid levels in people with gout. It works by helping the kidneys get rid of uric acid from the body. Increased uric acid levels can cause gout.


How to use LESINURAD - ORAL

HOW TO USE: See also Warning section. Read the Medication Guide provided by your pharmacist before you start taking lesinurad and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with food as directed by your doctor, usually once daily in the morning with your other uric acid medication. Drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug. If you are on restricted fluid intake, consult your doctor for further instructions. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. You may have more gout attacks after starting this medicine while your body removes extra uric acid. Lesinurad is not a pain reliever. Your doctor may prescribe medication (including colchicine, NSAIDs such as ibuprofen, naproxen, or indomethacin) to prevent/treat a gout attack while you are taking lesinurad. Continue to take lesinurad and your prescribed medicines for gout attacks as directed by your doctor. Tell your doctor if your condition lasts or gets worse.

Side Effects

SIDE EFFECTS: Heartburn may occur. If this effect lasts or gets worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as lower back pain, painful/difficult urination, nausea/vomiting, change in the amount of urine). A small number of people who took this medication had heart-related problems or stroke. However, it is not known if this medication caused these problems. Get medical help right away if you have any of these very serious side effects, including: weakness on one side of the body, sudden vision changes, confusion, chest/jaw/left arm pain, unusual sweating. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking lesinurad, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, cancer treatment, a certain inherited disease (Lesch-Nyhan syndrome). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of lesinurad from your body, which may affect how lesinurad works. An example is valproic acid. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use reliable backup birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. Aspirin can decrease the effects of this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

ZURAMPIC 200 MG TABLET
ZURAMPIC 200 MG TABLET
ZURAMPIC 200 MG TABLET
color
blue
shape
oblong
imprint
LES200

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Faq for LESINURAD - ORAL

Lesinurad is an oral medication that belongs to a class of drugs known as urate transport inhibitors. It is used in combination with other medications to help lower blood uric acid levels in adults who have gout.

Lesinurad works by blocking a specific protein transporter in the kidneys called URAT1. This transporter is responsible for reabsorbing uric acid back into the blood, contributing to high levels of uric acid in the body. By inhibiting URAT1, Lesinurad helps increase uric acid excretion through the urine, reducing the overall levels in the body.

The standard recommended dosage of Lesinurad is 200 mg once daily, taken orally with or without food. It is important to follow your healthcare provider's instructions regarding dosage and duration of treatment.

Lesinurad is designed to be used in combination with a xanthine oxidase inhibitor (XOI) medication, such as allopurinol or febuxostat. Combining Lesinurad with an XOI increases the effectiveness of reducing blood uric acid levels and preventing gout attacks.

Yes, like any medication, Lesinurad can cause side effects. Some common side effects may include headache, flu-like symptoms, heartburn, muscle aches, and increased blood creatinine levels. It is important to discuss any unusual or severe side effects with your doctor.

Lesinurad is not recommended for individuals with severe kidney impairment, end-stage renal disease, or a history of kidney stones. It should also be avoided in patients who are taking certain medications, such as strong inhibitors of transporter proteins or P-glycoprotein inducers. Consult your healthcare provider for a complete list of contraindications and precautions.

Lesinurad should not be used during pregnancy or while breastfeeding. It is advisable to discuss alternative treatment options with your healthcare provider if you are pregnant or planning to become pregnant.

Lesinurad typically starts reducing blood uric acid levels within 24 hours of starting treatment. However, it may take several weeks to months to achieve optimal results. Follow your doctor's instructions and have regular check-ups to monitor your progress.

Lesinurad is not a cure for gout, but rather a medication that helps manage and prevent gout attacks by lowering blood uric acid levels. It should be used as part of a comprehensive treatment plan that includes lifestyle changes, such as dietary modifications and increased fluid intake.

Lesinurad is an oral medication used for the treatment of high levels of uric acid in the blood in people with gout. It is used in combination with other medications to lower uric acid levels and prevent gout attacks.

No, Lesinurad is not suitable for everyone with gout. It should not be used by people with severe kidney disease (including dialysis patients), people receiving cancer chemotherapy, or people with a history of Lesinurad-associated severe skin reactions. It is essential to consult a healthcare professional before starting Lesinurad to assess suitability.

Yes, Lesinurad can interact with certain medications. It is important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and herbal supplements, to avoid any potential interactions.

Yes, Lesinurad is typically used in combination with a xanthine oxidase inhibitor (such as allopurinol or febuxostat) for the management of gout. Combining Lesinurad with these medications can effectively lower uric acid levels and reduce gout attacks.

No, Lesinurad is not a cure for gout. It is a long-term treatment aimed at managing high uric acid levels and reducing the frequency of gout attacks. It is important to continue taking Lesinurad as prescribed by a healthcare professional for ongoing management of gout.

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Warning

WARNING: Lesinurad has caused very serious kidney problems, especially when it is used alone to lower uric acid levels. It should always be used in combination with another medication. If you need to stop your other uric acid medication, then you should also stop this medication. Consult your doctor for more details.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.