IXAZOMIB - ORAL

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IXAZOMIB - ORAL

PHONETIC PRONUNCIATION: (ix-AZ-oh-mib)

COMMON BRAND NAME(S): Ninlaro

GENERIC NAME(S): ixazomib citrate

Uses

USES: This medication is used with other medications (such as lenalidomide, dexamethasone) to treat a certain type of cancer (multiple myeloma). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.


How to use IXAZOMIB - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking ixazomib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth at least 1 hour before or 2 hours after food as directed by your doctor, usually once a week for 3 weeks, then stopping the medication for 1 week. This is one cycle of treatment. Continue taking the medication this way as directed by your doctor. Swallow the medication whole with water. Do not crush, chew, or open the capsules. If you vomit after taking a dose, do not take another dose at that time. Take your next dose at the regular time. The dosage is based on your medical condition, lab tests, and response to treatment. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time and day of the week on the weeks you take the medication. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. If a capsule breaks, avoid skin and eye contact with the contents of the capsule. If the contents of the capsule get on the skin, wash the area with plenty of water and soap. If the contents of the capsule get in the eyes, flush the eyes with plenty of water. Since this drug can be absorbed through the skin and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication.

Side Effects

SIDE EFFECTS: Diarrhea, nausea/vomiting, constipation, dry eyes, blurred vision, or eye redness/itching/discharge may occur. Nausea, vomiting, and diarrhea can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea, vomiting, and diarrhea. Eating several small meals, not eating before treatment, or limiting activity may help lessen the nausea and vomiting. If any of these effects last or get worse, tell your doctor or pharmacist promptly. People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk. Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, signs of infection (such as sore throat that doesn't go away, fever, chills), shingles skin rash/pain (herpes zoster), numbness/tingling of arms/legs, swelling hands/ankles/feet, sudden/unexplained weight gain, symptoms of liver disease (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine). Ixazomib can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice any other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking ixazomib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease. This drug may cause blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Since this drug can be absorbed through the skin and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication. Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while taking ixazomib. Ixazomib may harm an unborn baby. Women and men should ask about reliable forms of birth control while taking this medication and for 90 days after stopping treatment. Women should also ask about using additional reliable forms of non-hormonal birth control (such as condoms, diaphragm with spermicide) if they are using hormonal birth control (such as birth control pills). If you or your partner become pregnant, talk to your doctor right away about the risks and benefits of this medication. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using this drug and for 90 days after stopping treatment. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of ixazomib from your body, which may affect how ixazomib works. Examples include rifamycins (such as rifampin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

NINLARO 2.3 MG CAPSULE
NINLARO 2.3 MG CAPSULE
NINLARO 2.3 MG CAPSULE
color
light pink
shape
oblong
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Takeda, 2.3 mg
NINLARO 2.3 MG CAPSULE
NINLARO 2.3 MG CAPSULE
NINLARO 2.3 MG CAPSULE
color
light pink
shape
oblong
imprint
Takeda, 2.3 mg
NINLARO 3 MG CAPSULE
NINLARO 3 MG CAPSULE
NINLARO 3 MG CAPSULE
color
light gray
shape
oblong
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Takeda, 3.0 mg
NINLARO 3 MG CAPSULE
NINLARO 3 MG CAPSULE
NINLARO 3 MG CAPSULE
color
light gray
shape
oblong
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Takeda, 3.0 mg
NINLARO 4 MG CAPSULE
NINLARO 4 MG CAPSULE
NINLARO 4 MG CAPSULE
color
light orange
shape
oblong
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Takeda, 4.0 mg
NINLARO 4 MG CAPSULE
NINLARO 4 MG CAPSULE
NINLARO 4 MG CAPSULE
color
light orange
shape
oblong
imprint
Takeda, 4.0 mg

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Faq for IXAZOMIB - ORAL

Ixazomib is an oral medication that belongs to a class of drugs known as proteasome inhibitors. It is used in the treatment of multiple myeloma, a type of cancer that affects plasma cells in the bone marrow.

Ixazomib works by inhibiting the activity of proteasomes, which are responsible for breaking down proteins in cells. By inhibiting proteasomes, Ixazomib helps to prevent the growth and spread of cancer cells in multiple myeloma.

Ixazomib is taken orally in the form of capsules. It is usually taken once a week, on the same day each week. It should be taken at least one hour before or at least two hours after eating.

Common side effects of Ixazomib may include nausea, vomiting, diarrhea, constipation, tiredness, rash, peripheral neuropathy (numbness or tingling in hands or feet), back pain, and decreased appetite. It is important to report any severe or persistent side effects to your doctor.

It is important to inform your doctor about any other medications you are taking, including over-the-counter drugs and herbal supplements, as they may interact with Ixazomib. Additionally, it is advisable to use effective contraception during treatment with Ixazomib, as it may cause harm to an unborn baby.

The response to Ixazomib treatment can vary from person to person. In some cases, improvement may be seen within a few weeks, while in others it may take several months. It is important to follow your doctor's instructions and continue taking Ixazomib for the prescribed duration.

Ixazomib should be taken at least one hour before or at least two hours after eating. This is to ensure optimal absorption of the medication.

If you miss a dose of Ixazomib, take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed dose.

Ixazomib is often used in combination with other medications, such as dexamethasone and lenalidomide, for the treatment of multiple myeloma. The specific combination therapy may vary depending on individual patient factors, and it is important to consult with your doctor to determine the most appropriate treatment plan.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.