ISOSORBIDE DINITRATE/HYDRALAZINE - ORAL

ISOSORBIDE DINITRATE/HYDRALAZINE - ORAL

PHONETIC PRONUNCIATION: (EYE-soe-SOR-bide dye-NYE-trate/hye-DRAL-a-zeen)

COMMON BRAND NAME(S): Bidil

GENERIC NAME(S): isosorbide dinitrate/hydralazine HCl

Uses

USES: This medication contains 2 drugs (hydralazine and isosorbide dinitrate) and is used with other medications to treat heart failure. Both drugs are known as vasodilators. They work by relaxing and widening blood vessels so blood can flow more easily to the heart.


How to use ISOSORBIDE DINITRATE/HYDRALAZINE - ORAL

HOW TO USE: Take this medication by mouth, usually 3 times daily or as directed by your doctor. The dosage is based on your medical condition and response to treatment. Your doctor may start you at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased. Tell your doctor if your condition worsens.

Side Effects

SIDE EFFECTS: Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Headache is often a sign that this medication is working. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen). If the headaches continue or become severe, tell your doctor promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may rarely cause nerve problems. Tell your doctor promptly if you experience numbness or tingling. Your doctor may recommend a vitamin B6 supplement (pyridoxine). Tell your doctor right away if any of these unlikely but serious side effects occur: severe tiredness, aching/swollen joints, rash on nose and cheeks, swollen glands, signs of kidney problems (such as change in the amount of urine, bloody/pink urine), signs of infection (such as fever, chills, persistent sore throat), easy bruising/bleeding, fainting, fast/irregular/pounding heartbeat. Seek immediate medical attention if this rare but serious side effect occurs: chest/jaw/left arm pain. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to either isosorbide dinitrate or hydralazine; or to similar drugs (such as isosorbide mononitrate, nitroglycerin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: other heart problems (such as recent heart attack, rheumatic heart disease of the mitral valve), previous stroke, low blood pressure, blood vessel problems, loss of too much body water (dehydration), recent head injury, anemia, kidney problems. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist that you are using this medication. Older adults may be more sensitive to the side effects of this drug, especially dizziness and lightheadedness, which could increase the risk of falls. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Hydralazine passes into breast milk. It is unknown if isosorbide dinitrate passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: certain drugs to treat migraine headaches (ergot alkaloids such as ergotamine), drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), riociguat. Some products have ingredients that could worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Isosorbide dinitrate is very similar to isosorbide mononitrate. Do not use medications containing isosorbide mononitrate while using isosorbide dinitrate. This medication may interfere with certain laboratory tests (including blood cholesterol levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow heartbeat, vision changes, severe nausea/vomiting, sweating, cold/clammy skin, bluish fingers/toes/lips, chest/jaw/left arm pain.

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BIDIL TABLET

color
orange
shape
round
imprint
20, N

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Faq for ISOSORBIDE DINITRATE/HYDRALAZINE - ORAL

- Isosorbide Dinitrate/Hydralazine is used to treat heart failure in certain patients. It helps improve the symptoms of heart failure and increases the ability to exercise.

- Isosorbide Dinitrate relaxes and widens blood vessels, making it easier for the heart to pump blood. Hydralazine also relaxes blood vessels, reducing the workload on the heart.

- The common side effects may include headaches, dizziness, lightheadedness, nausea, flushing of the face, and rapid heartbeat.

- Take this medication by mouth with or without food as directed by your doctor. Usually, it is taken three times a day, with the last dose taken in the early evening to avoid being awakened by side effects during the night.

- Drinking alcohol can increase some of the side effects of Isosorbide Dinitrate/Hydralazine, such as dizziness and lightheadedness. It is advisable to limit alcohol consumption while on this medication.

- Isosorbide Dinitrate/Hydralazine may be harmful to an unborn baby. Consult your doctor if you are pregnant or planning to become pregnant.

- If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

- It is important to inform your doctor about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Some medications may interact with Isosorbide Dinitrate/Hydralazine, so it is crucial to discuss any potential drug interactions.

- The effects of Isosorbide Dinitrate/Hydralazine may take several weeks to be noticeable. It is important to continue taking the medication as prescribed, even if you feel well.

Isosorbide dinitrate/hydralazine oral medication is used to treat heart failure in certain patients of African descent.

Isosorbide dinitrate/hydralazine oral medication works by relaxing and widening the blood vessels, which helps improve blood flow and reduce the workload on the heart.

Common side effects of isosorbide dinitrate/hydralazine oral medication may include headache, dizziness, lightheadedness, fast heartbeat, and flushing of the face.

It is generally not recommended to take isosorbide dinitrate/hydralazine oral medication during pregnancy unless absolutely necessary. Consult with your doctor for specific recommendations.

Isosorbide dinitrate/hydralazine oral medication is typically taken by mouth, usually 3 to 4 times a day, or as prescribed by your doctor. Follow the instructions provided by your healthcare professional.

It is important to inform your doctor about all the medications you are taking, including prescription, over-the-counter, and herbal products, as some medications may interact with isosorbide dinitrate/hydralazine. Your doctor will determine the best course of action based on your specific situation.

The effects of isosorbide dinitrate/hydralazine oral medication may be felt within a few hours of taking the medication, but it may take several weeks to see the full benefits. It is important to continue taking the medication as prescribed by your doctor.

It is important not to stop taking isosorbide dinitrate/hydralazine oral medication suddenly without consulting your doctor. Suddenly stopping the medication may worsen your condition. Your doctor will provide guidance on when and how to taper off the medication if necessary.

Isosorbide dinitrate/hydralazine may cause dizziness or lightheadedness, especially when standing up quickly. Avoid driving or operating machinery until you know how the medication affects you. Also, inform your doctor if you have any liver or kidney problems, as dosage adjustments may be necessary.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.