ISONIAZID - ORAL

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ISONIAZID - ORAL

PHONETIC PRONUNCIATION: (EYE-soe-NYE-a-zid)

COMMON BRAND NAME(S): Niazid

GENERIC NAME(S): isoniazid

Uses

USES: Isoniazid is used with other medications to treat active tuberculosis (TB) infections. It is also used alone to prevent active TB infections in people who may be infected with the bacteria (people with positive TB skin test). Isoniazid is an antibiotic and works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.


How to use ISONIAZID - ORAL

HOW TO USE: Take this medication by mouth on an empty stomach (1 hour before or 2 hours after meals) as directed by your doctor. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you also take antacids that contain aluminum, take this medication at least 1 hour before the antacid. Dosage is based on your age, weight, medical condition, and response to treatment. For the best effect, take this drug at evenly spaced times. If you are taking this medication daily, take it at the same time each day. If you are taking this medication on a weekly schedule, take it on the same day(s) of the week and at the same time each day. Mark the days on the calendar when you need to take the medication. Continue to take this medication (and other TB medications) until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early or skipping doses may allow the bacteria to continue to grow, which may result in a return of the infection and cause the infection to be more difficult to treat (resistant). Your doctor may also direct you to take vitamin B6 (pyridoxine) to help prevent certain side effects (such as nerve problems) from isoniazid. Follow your doctor's instructions carefully. Isoniazid may interact with foods containing tyramine/histamine (such as cheese, red wine, certain types of fish). This interaction may cause increased blood pressure, flushing of the skin, headache, dizziness, or fast/pounding heartbeat. Tell your doctor right away if any of these symptoms occur. Your doctor may recommend that you follow a special diet while taking this medication. Consult your doctor for more details. Tell your doctor if your condition persists or worsens.

Side Effects

SIDE EFFECTS: See also Warning section. Nausea/vomiting or stomach upset may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: numbness/tingling of arms/legs, painful/swollen joints. Tell your doctor right away if any of these rare but serious side effects occur: increased thirst/urination, vision changes, easy bruising/bleeding, mental/mood changes (such as confusion, psychosis), seizures. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever that doesn't go away, new or worsening lymph node swelling, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: See also Warning section. Before taking isoniazid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: previous severe reaction from isoniazid (such as liver disease), liver disease, alcohol use, HIV infection, kidney disease, diabetes, numbness/tingling of arms/legs (peripheral neuropathy), recent childbirth. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Alcohol may increase the risk of liver disease. Avoid alcoholic beverages while using this medication. This product may cause live bacterial vaccines (such as BCG vaccine) to not work as well. Therefore, do not have any immunizations/vaccinations while using this medication unless your doctor tells you to. Liquid forms of this medication may contain sugar. Caution is advised if you have diabetes or any other condition that requires you to limit/avoid sugar. Ask your doctor or pharmacist about using this product safely. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This product passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: acetaminophen, certain azole antifungals (itraconazole, ketoconazole), disulfiram, MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), phenytoin, SSRI antidepressants (such as fluoxetine, sertraline), valproic acid. This medication may interfere with certain laboratory tests (including urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: vision changes, slow/shallow breathing, severe drowsiness.

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Faq for ISONIAZID - ORAL

Isoniazid is an antibiotic medication used in the treatment of tuberculosis (TB) and to prevent TB infection in individuals who are at a higher risk.

Isoniazid works by stopping the growth of the bacteria that causes tuberculosis.

Isoniazid should be taken exactly as prescribed by your doctor. It is usually taken once a day on an empty stomach, either one hour before or two hours after meals.

If you miss a dose of Isoniazid, take it as soon as you remember. However, if it is already close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.

Common side effects of Isoniazid include nausea, vomiting, loss of appetite, and mild stomach upset. More serious side effects may include liver problems, numbness or tingling in the hands or feet, and mental/mood changes. It is important to report any severe or persistent side effects to your doctor.

You should avoid alcohol while taking Isoniazid, as it can increase the risk of liver damage.

Yes, Isoniazid can interact with several medications. It is important to inform your doctor about all the medications you are currently taking, including prescription, over-the-counter, and herbal products.

The duration of treatment with Isoniazid can vary depending on the condition being treated. It is important to take the medication for the full prescribed length of time, even if your symptoms improve.

If you are pregnant or breastfeeding, it is important to discuss the potential risks and benefits of taking Isoniazid with your doctor.

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Warning

WARNING: Isoniazid has rarely caused very serious (possibly fatal) liver disease. The risk of liver disease is increased in people who are 35 years and older, who use alcohol or illegal injection drugs, or who currently have long-term liver problems. Tell your doctor right away if you develop symptoms of liver disease, including persistent nausea/vomiting, severe stomach/abdominal pain, unusual weakness/tiredness, dark urine, yellowing eyes/skin. Your doctor should order liver function tests while you are taking this medication. Keep all medical and laboratory appointments.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.