SIDE EFFECTS: Nausea, vomiting, diarrhea, headache, constipation, cough, and trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Symptoms of an infusion reaction that may occur during isavuconazonium treatment include dizziness, fainting, trouble breathing, chills, numb/tingling skin, changes in your sense of touch. Your doctor will monitor you closely and will stop your treatment if a reaction occurs. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: muscle cramps/spasms, weakness, irregular heartbeat, swelling hands/ankles/feet, back pain, mental/mood changes (such as confusion, anxiety). Get medical help right away if you have any very serious side effects, including: fast/irregular/pounding heartbeat, chest pain, fainting, signs of kidney problems (such as change in the amount of urine), seizures. Isavuconazonium may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: persistent nausea/vomiting, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine. Isavuconazonium can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, tell your doctor right away if you develop any rash. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using isavuconazonium, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, family history of certain heart problems (short QT syndrome, abnormal heart rate/rhythm). This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. It is unknown if this drug passes into breast milk. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include bosutinib, lomitapide, simeprevir, tolvaptan, among others. Other medications can affect the removal of isavuconazonium from your body, which may affect how isavuconazonium works. Examples include certain azole antifungals (such as itraconazole, ketoconazole), certain drugs used to treat chronic hepatitis C (boceprevir, telaprevir), certain HIV protease inhibitors (such as nelfinavir, saquinavir), nefazodone, certain rifamycins (such as rifabutin, rifampin), certain drugs used to treat seizures (such as carbamazepine, phenobarbital), St. John's wort, among others.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.