IMIPENEM/CILASTATIN - INJECTION

IMIPENEM/CILASTATIN - INJECTION

PHONETIC PRONUNCIATION: (IM-i-PEM-em/SYE-la-STAT-in)

COMMON BRAND NAME(S): Primaxin

GENERIC NAME(S): imipenem/cilastatin sodium

Uses

USES: This medication is used to treat a wide variety of bacterial infections. This medication is known as a carbapenem-type antibiotic. It works by stopping the growth of bacteria.


How to use IMIPENEM/CILASTATIN - INJECTION

HOW TO USE: This medication is given by injection into a muscle or vein, usually every 6 to 8 hours or as directed by your doctor. The dosage is based on your medical condition and response to treatment. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely. For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same time(s) every day. Continue to use this medication until the full prescribed treatment period is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition persists or worsens.

Side Effects

SIDE EFFECTS: Swelling, redness, pain, or soreness at the injection site may occur. This medication may also rarely cause upset stomach, nausea, vomiting, or diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: dark urine, easy bruising/bleeding, hearing changes (e.g., decreased hearing, ringing in the ears), mental/mood changes (e.g., confusion, hallucinations), persistent sore throat/fever, tingling hands/feet, yellowing eyes/skin, muscle twitching/spasms. Get medical help right away if any of these rare but very serious side effects occur: seizures, unusual weakness. This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool. Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using imipenem with cilastatin, tell your doctor or pharmacist if you are allergic to either of its ingredients; or to penicillins or cephalosporins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis). This medication may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Though there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: ganciclovir, other antibiotics, divalproate/valproic acid. Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details. This medication may interfere with certain laboratory tests (e.g., urine glucose), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: seizures.

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Faq for IMIPENEM/CILASTATIN - INJECTION

Imipenem/Cilastatin injection is an antibiotic medication used to treat serious infections caused by susceptible bacteria, such as intra-abdominal infections and urinary tract infections.

Imipenem is a carbapenem antibiotic that works by inhibiting the bacterial cell wall synthesis, leading to cell death. Cilastatin is added to the medication to prevent the breakdown of imipenem in the kidneys.

Common side effects may include nausea, vomiting, diarrhea, headache, rash, and injection site reactions. Inform your healthcare provider if you experience any severe or persistent side effects.

Imipenem/Cilastatin injection is typically given by a healthcare professional as an intravenous infusion into a vein. The dosage and duration of treatment will depend on the specific infection being treated.

Imipenem/Cilastatin injection is generally not recommended for use during pregnancy unless the potential benefits outweigh the risks. It is also advised to avoid breastfeeding while receiving this medication.

If you miss a dose, it is important to inform your healthcare provider as soon as possible. They will determine the best course of action, which may include adjusting the dosing schedule or providing a make-up dose.

Imipenem/Cilastatin injection may interact with certain medications, such as valproic acid, which can decrease the effectiveness of valproic acid. It is important to inform your healthcare provider about all medications and supplements you are taking before starting this antibiotic.

Imipenem/Cilastatin injection should be stored at room temperature, away from light and moisture. It should be kept out of the reach of children and properly disposed of when no longer needed.

Yes, allergic reactions to Imipenem/Cilastatin injection are possible. Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, rash, or itching after receiving this medication.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.