FOSAPREPITANT - INJECTION

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FOSAPREPITANT - INJECTION

PHONETIC PRONUNCIATION: (FOS-a-PRE-pi-tant)

COMMON BRAND NAME(S): Emend

GENERIC NAME(S): fosaprepitant dimeglumine

Uses

USES: Fosaprepitant is used with other medications to help prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). Fosaprepitant works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting. This medication will not treat nausea or vomiting that has already started. Ask your doctor what you should do if you already have nausea or vomiting.


How to use FOSAPREPITANT - INJECTION

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using fosaprepitant and each time you get treatment. If you have any questions, ask your doctor or pharmacist. This medication is given by injection into a vein by a health care professional. It is given as directed by your doctor, usually 30 minutes before the start of chemotherapy. Your doctor may also direct you to take a form of this medication given by mouth (aprepitant) for the next 2 days. Follow your doctor's instructions carefully. Children's dosage is based on weight and age. If you have any questions, ask your doctor or pharmacist. Fosaprepitant may rarely cause severe allergic reactions (such as flushing, redness, or trouble breathing) while it is being given. Your doctor may decide to stop the infusion if this happens. Tell your healthcare professional right away if you have any of symptoms of a severe allergic reaction during your infusion. If the infusion is stopped, do not use fosaprepitant again. Tell your doctor if you vomit or feel nauseated.

Side Effects

SIDE EFFECTS: See also How to Use section. Tiredness or hiccups may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: redness/sores/pain/swelling at or near the injection site. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using fosaprepitant, tell your doctor or pharmacist if you are allergic to it; or to aprepitant; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of fosaprepitant from your body, which may affect how fosaprepitant works. Examples include azole antifungals (such as itraconazole, ketoconazole), diltiazem, macrolide antibiotics (such as clarithromycin, erythromycin), nefazodone, HIV protease inhibitors (such as ritonavir, nelfinavir), rifamycins (such as rifampin, rifabutin), St. John's wort, certain anti-seizure medicines (such as carbamazepine, phenytoin), among others. Fosaprepitant can both speed up or slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include flibanserin, lomitapide, pimozide, among others. If you take warfarin, this drug may affect how well warfarin works in your body. Your doctor should test your blood during the 2 weeks after your fosaprepitant treatment to measure how well warfarin is working. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after stopping this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. Fosaprepitant is very similar to aprepitant. Do not use aprepitant while using fosaprepitant.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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EMEND 150 MG VIAL
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EMEND 150 MG VIAL
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Faq for FOSAPREPITANT - INJECTION

Fosaprepitant injection is used to prevent nausea and vomiting caused by chemotherapy or surgery.

Fosaprepitant injection works by blocking a substance in the brain called neurokinin 1 (NK1) receptor, which is responsible for triggering nausea and vomiting.

Fosaprepitant injection is given as an intravenous infusion by a healthcare professional.

Common side effects of Fosaprepitant injection include fatigue, constipation, loss of appetite, headache, and hiccups.

Fosaprepitant injection has a half-life of approximately 9-13 hours, meaning it takes that amount of time for half of the drug to be eliminated from the body.

Fosaprepitant injection is not approved for use in children under 18 years of age.

Fosaprepitant injection may interact with certain medications, such as warfarin, dexamethasone, and certain birth control pills. It is important to inform your doctor about all the medications you are taking before receiving Fosaprepitant injection.

Fosaprepitant injection, when used in combination with other antiemetic (anti-nausea) medications, has been shown to be effective in preventing nausea and vomiting associated with chemotherapy and surgery.

Fosaprepitant injection is typically given as a single dose before chemotherapy or surgery. However, your doctor may prescribe a different dosing schedule based on your individual needs.

Fosaprepitant is given as an infusion into a vein over 20 to 30 minutes, usually 30 minutes before chemotherapy.

Fosaprepitant injection should be used with caution in patients with liver problems, as it can affect liver function. It may also interact with certain medications, so inform your healthcare provider about all the medicines you are taking.

Fosaprepitant injection should only be used during pregnancy if clearly needed. It is not known if it passes into breast milk, so breastfeeding women should consult their healthcare provider before using it.

The effect of Fosaprepitant injection typically lasts for up to 5 days after a single dose.

Fosaprepitant injection should be stored in the refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). It should not be frozen.

If you miss a dose of Fosaprepitant injection, contact your healthcare provider to reschedule it as soon as possible.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.