FLUOROURACIL - INJECTION

FLUOROURACIL - INJECTION

PHONETIC PRONUNCIATION: (flewr-oh-YOUR-uh-sill)

COMMON BRAND NAME(S): Adrucil

GENERIC NAME(S): fluorouracil

Uses

USES: Fluorouracil is used to treat various types of cancer. It is a chemotherapy drug that is used alone or in combination with other medications to slow or stop cancer cell growth.


How to use FLUOROURACIL - INJECTION

HOW TO USE: This medication is usually given by injection into a vein by a health care professional. It may also be given by other methods of injection depending upon your medical condition. The dosage is based on your medical condition, body size, and response to therapy.

Side Effects

SIDE EFFECTS: Nausea, vomiting, loss of appetite, dry/itchy skin, or skin darkening may occur. Nausea and vomiting can be severe. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. Not eating before your treatment may help relieve vomiting. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Mild diarrhea is also a common side effect. However, diarrhea can rarely become persistent or severe, causing very serious problems due to a loss of too much body water (dehydration). Tell your doctor right away if you develop: persistent/severe diarrhea, abdominal or stomach pain/cramping, or blood/mucus in your stool. Temporary hair loss may occur. Normal hair growth should return after treatment has ended. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Hand and foot problems sometimes occur with fluorouracil use. You can prevent or reduce these problems by protecting your hands and feet from a great deal of heat or pressure. For example, avoid taking hot baths/showers, handwashing dishes with hot water, taking long walks, and rubbing your hands/feet. Tell your doctor right away if you develop the following symptoms on your hands/feet: redness, peeling skin, blisters, pain, numbness, tingling, or swelling. If you develop these symptoms, consult your doctor for treatment options (e.g., reducing your dose or stopping fluorouracil therapy, applying ice packs to the hands/feet). Tell your doctor right away if you have any serious side effects, including: headache, mental/mood changes (e.g., confusion), vision changes, unusual eye movements, loss of coordination, unusual tiredness. Get medical help right away if any of these rare but very serious side effects occur: easy bruising/bleeding, blood in the urine, black/bloody stools, vomit that looks like coffee grounds, stomach/abdominal pain, chest pain, jaw/left arm pain, fast/slow/irregular heartbeat, mouth sores, sore throat, painful swallowing, heartburn, pain/redness/swelling of the arms/legs. This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection such as fever, chills or persistent sore throat. A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Fluorouracil can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, get medical help right away if you develop a rash. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using fluorouracil, tell your doctor or pharmacist if you are allergic to it; or to flucytosine; or to capecitabine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor nutrition, decreased bone marrow function/blood cell disorders (e.g., anemia, leukopenia, thrombocytopenia), a certain enzyme deficiency (dihydropyrimidine dehydrogenase - DPD), a serious infection, liver problems, kidney problems. Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine. Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured. Wash your hands well to prevent the spread of infections. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness. This medication is not recommended for use during pregnancy. It may cause harm to an unborn baby. Women of childbearing age and men should use reliable form(s) of birth control during therapy and for some time afterwards. Consult your doctor for more details. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: warfarin. Fluorouracil is very similar to flucytosine and capecitabine. Do not use medications containing flucytosine or capecitabine while using fluorouracil.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.