ERTUGLIFLOZIN/SITAGLIPTIN - ORAL

ERTUGLIFLOZIN/SITAGLIPTIN - ORAL

PHONETIC PRONUNCIATION: (ER-too-gli-FLOE-zin/SIT-a-GLIP-tin)

COMMON BRAND NAME(S): Steglujan

GENERIC NAME(S): ertugliflozin pidolate/sitagliptin phosphate

Uses

USES: This medication is a combination of 2 drugs: ertugliflozin and sitagliptin. It is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Ertugliflozin works by increasing the removal of sugar by your kidneys. Sitagliptin works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes.


How to use ERTUGLIFLOZIN/SITAGLIPTIN - ORAL

HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking ertugliflozin/sitagliptin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. The dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Tell your doctor if your condition does not get better or if it gets worse (your blood sugar is too high or too low).

Side Effects

SIDE EFFECTS: Dizziness, lightheadedness, or frequent urination may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: signs of a urinary tract infection (such as burning/painful/frequent/urgent urination, pink/bloody urine), signs of kidney problems (such as change in the amount of urine, swelling legs/feet), joint pain, unusual skin blisters, signs of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain). Get medical help right away if you have any very serious side effects, including: signs of pancreatitis (such as nausea/vomiting that doesn't stop, loss of appetite, severe stomach/abdominal/back pain), unusual tiredness, trouble breathing. Use of this medication may cause a new yeast infection in the vagina or penis. You are more likely to get a yeast infection if you have had yeast infections in the genital area before. Uncircumcised men are also at a higher risk for infections. Tell your doctor right away if you have signs of yeast infection in the vagina (such as unusual vaginal discharge/burning/itching/odor) or in the penis (such as redness/itching/swelling of the penis, unusual discharge from the penis). Your doctor may direct you to use nonprescription antifungal products to treat these infections. Tell your doctor if your condition lasts or gets worse after treatment. This medication may increase the risk of amputation (especially of the toe). The risk is higher if you have poor blood flow in the legs, nerve problems, foot ulcers, or have had a previous amputation. To lessen the risk, check your feet regularly and tell your doctor if you have new pain, tenderness, sores, or ulcers on your legs or feet. This medication does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications, or if you do not consume enough calories from food, or if you do unusually heavy exercise. Talk with your doctor or pharmacist about whether the dose of your other diabetes medication needs to be lowered. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of high blood sugar (hyperglycemia) include increased thirst/urination. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased. This medication may cause you to lose too much body water (dehydration). This can lead to serious kidney damage. Drink plenty of fluids to prevent dehydration. Tell your doctor or pharmacist right away if you are not able to drink fluids as usual, or losing fluid (such as due to vomiting, diarrhea, or heavy sweating). Also, tell your doctor right away if you have any signs of dehydration, such as urinating less than usual, unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness/fainting. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to ertugliflozin or sitagliptin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease/failure (dialysis), heart failure, loss of too much body water (dehydration), low blood pressure, disease of the pancreas (pancreatitis), stones in your gallbladder (gallstones), yeast infections in the vagina or penis, blocked or narrowed blood vessels, usually in the leg, nerve problems (such as diabetic peripheral neuropathy), foot sores or ulcers, amputation. You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar and a high ketone level. It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Also, if you are eating less or not able to eat due to these conditions or any illness, this can lead to a high ketone level while you are taking this medication. Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar or ketone testing. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially dizziness/fainting (usually when standing), dehydration, and kidney disease. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin). It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Beta blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are not affected by these drugs. Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet. Your urine will test positive for glucose. Make sure lab personnel and all your doctors know you use this drug.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for ERTUGLIFLOZIN/SITAGLIPTIN - ORAL

Ertugliflozin/Sitagliptin is a combination medication that is taken orally to help control blood sugar levels in people with type 2 diabetes.

Ertugliflozin works by preventing the reabsorption of glucose by the kidneys, which leads to the excretion of excess glucose through urine. Sitagliptin works by increasing the levels of certain hormones in the body that stimulate the production of insulin and decrease the production of glucose in the liver.

Common side effects of Ertugliflozin/Sitagliptin may include urinary tract infections, increased urination, genital yeast infections, upper respiratory tract infections, and headache. However, not everyone will experience these side effects, and some may experience none at all.

Ertugliflozin/Sitagliptin is taken as directed by your doctor. It is usually taken once a day, with or without food. It is important to follow your doctor's instructions and not to change the dosage or stop the medication without consulting your doctor.

Yes, Ertugliflozin/Sitagliptin can be used in combination with other diabetes medications, such as metformin or insulin. However, it is important to inform your doctor about all the medications you are currently taking to avoid any potential drug interactions.

Ertugliflozin/Sitagliptin is not recommended for use in children below the age of 18 years. The safety and effectiveness of this medication in pediatric patients have not been established.

The onset of action of Ertugliflozin/Sitagliptin varies from person to person. It may take a few days to weeks to see a noticeable effect on blood sugar levels. It is important to monitor your blood sugar as directed by your doctor and make any necessary adjustments to your treatment plan.

If you miss a dose of Ertugliflozin/Sitagliptin, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Ertugliflozin/Sitagliptin is not recommended for use during pregnancy or breastfeeding. It is important to discuss the potential risks and benefits with your doctor before starting this medication if you are pregnant or planning to become pregnant.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.