CYCLOSPORINE MICROEMULSION SOLUTION - ORAL

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CYCLOSPORINE MICROEMULSION SOLUTION - ORAL

PHONETIC PRONUNCIATION: (SYE-kloe-SPOR-in MY-crow-ee-MULL-shun)

COMMON BRAND NAME(S): Gengraf, Neoral

GENERIC NAME(S): cyclosporine, modified

Uses

USES: Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Cyclosporine is also used to treat severe cases of rheumatoid arthritis and plaque psoriasis. In these conditions, the body's defense system (immune system) attacks healthy tissues. Cyclosporine belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help your body accept the new organ as if it were your own (in the case of an organ transplant) and to prevent further damage to your joints (in the case of rheumatoid arthritis) or skin (in the case of psoriasis).


How to use CYCLOSPORINE MICROEMULSION SOLUTION - ORAL

HOW TO USE: Take this medication by mouth as directed by your doctor, usually twice daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. The dosage is based on your weight, medical condition, lab tests, and response to treatment. Carefully measure the dose using the medicine syringe provided. Do not use a household spoon because you may not get the correct dose. To help improve the taste, you should mix the measured dose with a glass of orange or apple juice that is at room temperature. Do not switch juices often. Do not mix this medication with milk since it may cause it to have a bad taste. Make sure to use a glass cup and not a plastic cup. Drink all of the mixture right away. Do not prepare a supply in advance. To make sure you have taken all of the medication, rinse the glass with more juice, then mix and drink. Consult your pharmacist if you have any questions. Dry the outside of the syringe after use. Do not rinse it with water. If the syringe must be cleaned, make sure that it is completely dry before using it again. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. It may take up to 4 months before you get the full benefit of this drug for the treatment of rheumatoid arthritis and psoriasis. Tell your doctor if your condition does not get better (in 4 to 8 weeks for arthritis and in 2 to 4 weeks for psoriasis) or if it gets worse.

Side Effects

SIDE EFFECTS: See also Warning section. Shaking, headache, dizziness, unusual growth of body hair, nausea/vomiting, diarrhea, stomach upset, or flushing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Unusual growth and swelling of the gums may occur. Brush your teeth and floss daily to reduce this problem. See your dentist regularly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication. Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as a change in the amount of urine), signs of liver disease (such as nausea/vomiting that doesn't stop, dark urine, yellowing eyes/skin, stomach/abdominal pain), easy bruising/bleeding, unusual tiredness, muscle weakness/spasms, slow/irregular heartbeat, numb/tingling skin, severe leg pain. Get medical help right away if you have any very serious side effects, including: mental/mood changes (such as confusion, difficulty concentrating), vision changes, problems with speech, clumsiness, loss of coordination, weakness on one side of the body, seizures, chest pain. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking cyclosporine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, high blood pressure, cancer, skin lesions of unknown cause, radiation treatment (including light treatment with PUVA or UVB), mineral imbalance (such as low level of magnesium or high level of potassium), recent/current infections, high cholesterol/triglycerides levels. This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. This medication may contain alcohol. Caution is advised if you are pregnant or breastfeeding or have liver disease, alcohol dependence, or any other condition that requires you to limit/avoid alcohol in your diet. Ask your doctor or pharmacist about using this product safely. Cyclosporine can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). This medication may increase your risk of developing skin cancer. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Your doctor may direct you to avoid phototherapy while you use this product. Ask your doctor for details. This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be at greater risk for kidney problems or high blood pressure while using this drug. During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby or cause other problems with the baby such as being born too early (premature) or having low birth weight. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: coal tar, orlistat, other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab, tofacitinib), drugs that may increase potassium levels (such as potassium supplements, certain diuretics/"water pills" including amiloride, spironolactone), tacrolimus. Other medications can affect the removal of cyclosporine from your body, which may affect how cyclosporine works. Examples include boceprevir, bosentan, mifepristone, St. John's wort, telaprevir, among others. This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aliskiren, dabigatran, dronedarone, simeprevir, certain statins (such as pitavastatin, simvastatin), voxilaprevir, among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for CYCLOSPORINE MICROEMULSION SOLUTION - ORAL

Cyclosporine Microemulsion Solution - Oral is a medication used to prevent organ rejection in patients who have undergone an organ transplant. It works by suppressing the immune system.

Cyclosporine Microemulsion Solution - Oral should be taken exactly as prescribed by your doctor. It is usually taken once or twice daily, with or without food. It is important to continue taking this medication even if you feel well unless instructed otherwise by your doctor.

Common side effects include headache, nausea, vomiting, stomach upset, increased hair growth, tremors, and high blood pressure. If these side effects persist or worsen, you should contact your doctor.

It is important to avoid exposure to sunlight or UV rays as Cyclosporine can increase your skin's sensitivity to sunlight. Therefore, using protective clothing and sunscreen is advised. Also, avoid grapefruit or grapefruit juice while taking this medication as it may interact with Cyclosporine.

Yes, Cyclosporine can interact with certain medications such as antibiotics, antifungals, blood pressure medications, and certain immunosuppressants. It is crucial to inform your doctor about all the medications you are currently taking to avoid potential interactions.

Yes, it is important to follow any special dietary instructions provided by your doctor. Some patients may require a low-fat diet while taking this medication.

The effectiveness of Cyclosporine can vary depending on the individual and the specific condition being treated. It may take several weeks or even months to notice the full benefits of this medication.

It is generally not recommended to consume alcohol while taking Cyclosporine as it can increase the risk of certain side effects and may negatively interact with the medication. It is best to consult with your doctor regarding alcohol consumption.

If you accidentally miss a dose, take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

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Warning

WARNING: Cyclosporine lowers your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. This effect may also increase your risk of getting certain types of cancer (such as skin cancer, lymphoma). Tell your doctor right away if you have any signs of infection or cancer such as sore throat that doesn't go away, fever, chills, cough, burning/frequent urination, unusual skin changes, change in appearance or size of moles, unusual weight loss, swollen lymph glands, unusual lumps, night sweats. Cyclosporine can also cause high blood pressure and kidney problems. The risk of both problems increases with higher doses and longer treatment with this drug. Your doctor will monitor your blood pressure and kidney function while you take this medication. Psoriasis patients who have had certain previous treatments (such as coal tar, methotrexate, radiation treatment, light treatment with PUVA/UVB) are at increased risk to develop skin cancer. Talk to your doctor of the risks and benefits of this medication. Different brands of this medication may deliver different amounts of medication. Do not switch brands of cyclosporine without your doctor's permission and directions.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.