CRIZOTINIB - ORAL

CRIZOTINIB - ORAL

PHONETIC PRONUNCIATION: (kriz-OH-ti-nib)

COMMON BRAND NAME(S): Xalkori

GENERIC NAME(S): crizotinib

Uses

USES: Crizotinib is used to treat certain types of lung cancer. Crizotinib works by slowing or stopping the growth of lung cancer cells. It belongs to a class of drugs known as kinase inhibitors.


How to use CRIZOTINIB - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking crizotinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. Swallow whole with a glass of water. Do not crush or chew this medication. If you vomit after taking your dose of the medication, do not take an extra dose. Take the next dose of your medication at the regular time. The dosage is based on your medical condition, side effects, laboratory tests, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. Tell your doctor if your condition persists or worsens. Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

Side Effects

SIDE EFFECTS: Nausea, diarrhea, vomiting, dizziness, tiredness, headache, heartburn, change in taste, loss of appetite, mouth sores, joint pain, trouble sleeping, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as cough, sore throat, fever, chills). Tell your doctor right away if you have any serious side effects, including: vision changes (such as blurred/decreased vision, flashes of light, sensitivity to light, floaters), swelling of the legs/feet/hands. Get medical help right away if you have any very serious side effects, including: trouble breathing, cough with or without phlegm, eye pain/swelling/redness, fast/slow/irregular heartbeat, severe dizziness, fainting, easy bleeding/bruising, symptoms of liver problems (such as dark urine, persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin). This medication may affect male and female fertility. Consult your doctor for more details. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Crizotinib can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, tell your doctor right away if you develop any rash. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems. Crizotinib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using crizotinib, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using crizotinib safely. Crizotinib can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). This drug may make you dizzy or cause vision changes. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules. This medication is not recommended for use during pregnancy. It may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while taking this medication. Female patients should use reliable forms of birth control during and for at least 45 days after stopping this drug. Male patients and their female partner should use reliable forms of birth control during and for at least 3 months after stopping this drug. If you or your partner become pregnant or may be pregnant, tell your doctor right away. It is unknown if this drug passes into breast milk. Because of possible harm to a nursing infant, breast-feeding is not recommended while using this medication and for 45 days after stopping this medication. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: drugs that may slow the heartbeat (including digoxin, clonidine, beta-blockers such as atenolol/metoprolol, calcium channel blockers such as diltiazem/verapamil). Other medications can affect the removal of crizotinib from your body, which may affect how crizotinib works. Examples include azole antifungals (such as itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), drugs for seizures (such as carbamazepine, phenytoin), St. John's wort, among others. This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include alfentanil, ergots (such as ergotamine), fentanyl, tacrolimus, among others. Many drugs besides crizotinib may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, quinidine, procainamide, sotalol, and certain antipsychotic medications (such as pimozide, thioridazine, ziprasidone), among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Pfizer, CRZ 250

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Pfizer, CRZ 200

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Faq for CRIZOTINIB - ORAL

Crizotinib is an oral medication used to treat certain types of cancer, such as non-small cell lung cancer (NSCLC) that has a specific genetic mutation.

Crizotinib works by targeting and inhibiting specific proteins in cancer cells that promote their growth and division. It helps to slow down or stop the growth of cancer cells.

Some common side effects of Crizotinib include nausea, vomiting, diarrhea, constipation, weight gain, fatigue, dizziness, and visual disturbances. It is important to inform your doctor about any side effects.

Crizotinib is usually taken twice a day with or without food. It is important to follow the dosage instructions provided by your doctor or pharmacist. Do not crush, chew, or break the capsules.

Crizotinib may cause serious lung problems, liver problems, heart problems, and vision changes. It is important to inform your doctor about any pre-existing medical conditions or medications you are on before starting Crizotinib.

It is generally recommended to avoid alcohol while taking Crizotinib, as it may increase the risk of liver problems and other side effects.

No, Crizotinib is only effective in treating cancers that have specific genetic mutations. It is important to undergo genetic testing to determine if you are eligible for treatment with Crizotinib.

It is important to inform your doctor about all the medications, supplements, or herbal products you are taking before starting Crizotinib. Some medications may interact with Crizotinib and affect its effectiveness or cause side effects.

The duration of Crizotinib treatment varies depending on the individual and the response to treatment. Your doctor will monitor your condition and determine the appropriate duration of treatment.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.