C1-ESTERASE INHIBITOR (TREATMENT) - INJECTION

C1-ESTERASE INHIBITOR (TREATMENT) - INJECTION

PHONETIC PRONUNCIATION:

COMMON BRAND NAME(S): Berinert

GENERIC NAME(S): C1 esterase inhibitor

Uses

USES: This medication is used to treat the swelling problems that occur with a certain immune disease passed down through families (hereditary angioedema-HAE). HAE is caused by low levels or improper function of a natural substance produced by the body (C1-inhibitor). Symptoms such as rapid swelling of the hands, feet, limbs, face, tongue, or throat can occur. Swelling of the intestinal tract may cause symptoms such as abdominal cramps, diarrhea, or vomiting. Attacks of swelling may occur without reason. However, anxiety, stress, sickness, and surgery may trigger attacks in some people. This medication increases the level of C1-inhibitor to help treat attacks of sudden swelling due to hereditary angioedema.


How to use C1-ESTERASE INHIBITOR (TREATMENT) - INJECTION

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using C1-esterase inhibitor and each time you get a refill. If you have any questions, ask your doctor or pharmacist. This medication is given by injection into a vein, at the first signs of an HAE attack, as directed by your doctor. The dosage is based on weight and your medical condition. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. The solution is normally clear and colorless. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely. After giving yourself a dose of this medication, you should get medical help right away for follow-up treatment. Tell your doctor if your condition does not improve or if it worsens.

Side Effects

SIDE EFFECTS: A bad taste in the mouth may occur. Other side effects are uncommon. If you notice any unusual side effects, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may increase the risk for blood clots, especially when used at high doses. Get medical help right away if you notice any of the following rare but serious side effects: new swelling/pain in the arm/leg/abdomen, chest pain, loss of feeling or ability to move, slurred speech. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using C1-esterase inhibitor, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clots (such as in the lungs, legs). This medication is made from human blood. Even though the blood is carefully tested, and this medication goes through a special manufacturing process, there is an extremely small chance that you may get infections from the medication (for example, virus infections such as hepatitis). Consult your doctor or pharmacist for more information. Before traveling, talk to your doctor to make sure you have enough of this medication. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for C1-ESTERASE INHIBITOR (TREATMENT) - INJECTION

C1-esterase inhibitor injection is a medication used to treat hereditary angioedema (HAE). HAE is a genetic condition that causes swelling in various body parts like the hands, feet, face, or airways. This injection helps prevent and manage these swelling episodes.

C1-esterase inhibitor injection works by replacing or increasing the levels of C1-esterase inhibitor in the body. C1-esterase inhibitor is a protein that regulates certain enzymes involved in the immune response. By restoring the normal levels of this protein, the injection helps reduce the frequency and severity of angioedema attacks.

C1-esterase inhibitor injection is administered through a needle into a vein (intravenous injection). It is usually given by a healthcare professional in a hospital or clinic setting.

Common side effects of C1-esterase inhibitor injection may include headache, nausea, diarrhea, fever, dizziness, and injection site reactions. These side effects are generally mild and temporary.

The frequency of C1-esterase inhibitor injections may vary depending on the individual's needs and the severity of their condition. The injections can be given for acute attacks or for prophylactic (preventive) treatment. Your healthcare provider will determine the appropriate dosage and schedule for you.

Yes, some patients may be trained to self-administer C1-esterase inhibitor injection. However, this usually requires proper training and guidance from a healthcare professional.

It is important to discuss the use of C1-esterase inhibitor injection during pregnancy or breastfeeding with your healthcare provider. They can evaluate the potential risks and benefits and determine the best course of action.

If you miss a dose of C1-esterase inhibitor injection, contact your healthcare provider for instructions. It is important to stay on schedule with your treatments to effectively manage your condition.

There are no known significant drug interactions with C1-esterase inhibitor injection. However, it is always advisable to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, to ensure safe and effective treatment.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.