C1-ESTERASE INHIBITOR - SUBCUTANEOUS INJECTION

C1-ESTERASE INHIBITOR - SUBCUTANEOUS INJECTION

PHONETIC PRONUNCIATION:

COMMON BRAND NAME(S): Haegarda

GENERIC NAME(S): C1 esterase inhibitor

Uses

USES: This medication is used to help prevent swelling and painful attacks caused by a certain inherited disease (hereditary angioedema-HAE). Most people with this disease have too little of a certain substance produced by your body (C1-esterase inhibitor). Some people with this disease have normal amounts of the substance, but it doesn't work right. Anxiety, stress, illness, or surgery may trigger attacks in some people. Symptoms such as rapid swelling of the hands, feet, limbs, face, tongue, or throat can occur. Swelling of the belly may cause symptoms such as severe pain, nausea, vomiting, or diarrhea. This medication works by increasing the amount of C1-esterase inhibitor in your body. This medication should not be used to treat sudden swelling attacks caused by HAE. Ask your doctor ahead of time what to do if you have a sudden attack.


How to use C1-ESTERASE INHIBITOR - SUBCUTANEOUS INJECTION

HOW TO USE: Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist. If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. If the medication and the solution used to mix it have been refrigerated, allow both to come to room temperature before mixing. Do not warm up this medication any other way such as by heating in the microwave or placing in hot water. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely. Inject this medication under the skin on your abdomen or another site as directed by your doctor, usually every 3 or 4 days. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Do not inject into areas where the skin is itchy, swollen, painful, bruised, or red. Avoid injecting under skin where you have scars or stretch marks. The dosage is based on your medical condition, body weight, and response to treatment. Use this medication regularly to get the most benefit from it. Tell your doctor if your condition does not get better or if it gets worse.

Side Effects

SIDE EFFECTS: Pain/redness/swelling at the injection site, cold-like symptoms (such as runny/stuffy nose, sneezing, watery eyes), or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may increase the risk of blood clots (such as pulmonary embolism, stroke, heart attack, deep vein thrombosis), especially when used at high doses. You may be at increased risk for blood clots if you have a history of blood clots, heart/blood vessel disease, heart failure, stroke, or if you are immobile (such as on very long plane flights or being bedridden). If you use estrogen-containing products, these may also increase your risk. Before using this medication, if you have any of these conditions report them to your doctor or pharmacist. Get medical help right away if any of these side effects occur: shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, new pain/swelling/warmth in the groin/calf, sudden/severe headaches, trouble speaking, numbness/weakness on one side of the body, sudden vision changes. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using C1-esterase inhibitor, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clots (such as in the lungs, legs). This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. This medication is made from human blood. Even though the blood is carefully tested, and this medication goes through a special manufacturing process, there is an extremely small chance that you may get infections from the medication (for example, viruses such as hepatitis). Consult your doctor or pharmacist for more information. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for C1-ESTERASE INHIBITOR - SUBCUTANEOUS INJECTION

C1-esterase inhibitor is a protein that helps regulate the immune system by preventing unwanted activation of certain components involved in inflammation and immune response.

Subcutaneous injections of C1-esterase inhibitor are used for the treatment of hereditary angioedema (HAE), a rare genetic disorder characterized by recurrent episodes of swelling in various body parts. The injection helps to prevent or reduce the severity and duration of HAE attacks.

C1-esterase inhibitor is typically administered as a subcutaneous injection into the fatty tissue just beneath the skin. It can be self-administered by the patient or given by a healthcare professional.

The frequency of C1-esterase inhibitor injections varies based on individual needs and the specific treatment plan recommended by the healthcare provider. It may be recommended to be taken every few days or on a weekly basis, depending on the severity of HAE attacks.

Common side effects of C1-esterase inhibitor injections include injection-site reactions such as redness, swelling, itching, or pain. Other possible side effects may include fever, headache, nausea, and fatigue. It is important to inform your healthcare provider about any unusual or severe side effects experienced.

The safety of C1-esterase inhibitor injections during pregnancy or breastfeeding is not well-studied. It is essential to discuss the potential risks and benefits with a healthcare provider before using this medication in such situations.

C1-esterase inhibitor is approved for use in children with HAE. The appropriate dosage and administration guidelines for children may differ from those for adults, so it is important to follow the instructions provided by the healthcare provider.

C1-esterase inhibitor should be stored according to the manufacturer's instructions. It is usually recommended to store it in the refrigerator but should not be frozen. Always check the product packaging or consult a healthcare professional for specific storage guidelines.

If a dose is missed, it should be administered as soon as possible. However, if it is close to the next scheduled dose, the missed dose should be skipped and the regular dosing schedule should be followed. It is essential to consult a healthcare provider for specific guidance.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.