C1-ESTERASE INHIBITOR - INJECTION

C1-ESTERASE INHIBITOR - INJECTION

PHONETIC PRONUNCIATION:

COMMON BRAND NAME(S): Cinryze

GENERIC NAME(S): C1 esterase inhibitor

Uses

USES: This medication is used to help prevent swelling problems that occur with a certain immune disease passed down through families (hereditary angioedema-HAE). HAE is caused by low levels or improper function of a natural substance produced by the body (C1-inhibitor). Symptoms such as rapid swelling of the hands, feet, limbs, face, tongue, or throat can occur. Swelling of the intestinal tract may cause symptoms such as abdominal cramps, diarrhea, or vomiting. Attacks of swelling may occur without reason. However, anxiety, stress, sickness, and surgery may trigger attacks in some people. This medication increases the level of C1-inhibitor to help prevent attacks of sudden swelling due to hereditary angioedema.


How to use C1-ESTERASE INHIBITOR - INJECTION

HOW TO USE: Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist. This medication is given by injection into a vein, usually every 3 or 4 days, or as directed by your doctor. Dosage is based on your medical condition and response to treatment. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. The solution is normally clear and colorless to slightly blue, depending on the brand. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely. Use this medication regularly to get the most benefit from it. Tell your doctor if your condition does not improve or if it worsens.

Side Effects

SIDE EFFECTS: Headache may occur. Other side effects are uncommon. If you notice any unusual side effects, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may rarely cause blood clots (such as pulmonary embolism, stroke, heart attack, deep vein thrombosis), especially when used at high doses. You may be at increased risk for blood clots if you have a history of blood clots, heart/blood vessel disease, heart failure, stroke, or if you are immobile (such as on very long plane flights or being bedridden). If you use estrogen-containing products, these may also increase your risk. Before using this medication, if you have any of these conditions report them to your doctor or pharmacist. Get medical help right away if any of these side effects occur: shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, new pain/swelling/warmth in the groin/calf, sudden/severe headaches, trouble speaking, numbness/weakness on one side of the body, sudden vision changes. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using C1-inhibitor, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clots (such as in the lungs, legs). This medication is made from human blood. Even though the blood is carefully tested and this medication goes through a special manufacturing process, there is an extremely small chance that you may get infections from the medication (for example, virus infections such as hepatitis). Consult your doctor or pharmacist for more information. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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CINRYZE 500 UNIT VIAL

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Faq for C1-ESTERASE INHIBITOR - INJECTION

C1-esterase inhibitor injection is a medication used to treat hereditary angioedema (HAE), a rare genetic condition that causes sudden swelling in various parts of the body.

C1-esterase inhibitor injection works by replacing the deficient or dysfunctional C1-esterase inhibitor protein in individuals with HAE. This helps regulate the levels of certain chemicals in the body, reducing the frequency and severity of HAE attacks.

C1-esterase inhibitor injection is administered intravenously (IV) by a healthcare professional. It is typically given at a healthcare facility or under medical supervision.

Common side effects of C1-esterase inhibitor injection may include headache, nausea, diarrhea, skin reactions at the injection site, and flu-like symptoms. It is important to consult a healthcare professional if any side effects are experienced.

The frequency of C1-esterase inhibitor injection administration varies depending on the individual's specific treatment plan. It may be given as a preventive treatment on a regular basis or as an acute treatment during an HAE attack. The dosage and schedule are determined by a healthcare professional.

In some cases, individuals with HAE may be trained to self-administer C1-esterase inhibitor injection. This allows for greater flexibility in managing the condition and treating acute attacks. However, self-administration should only be done under medical supervision and guidance.

C1-esterase inhibitor injection is not known to have significant interactions with other medications. However, it is essential to inform the healthcare professional about all the medications, supplements, and herbal products being taken to minimize the risk of potential interactions.

There is limited data available on the use of C1-esterase inhibitor injection during pregnancy and breastfeeding. It is recommended to consult a healthcare professional before using this medication in such cases to assess the potential risks and benefits.

C1-esterase inhibitor injection starts working immediately after administration, providing relief from HAE symptoms. The duration of its effect may vary from person to person.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.