SIDE EFFECTS: This medication is expected to increase urination. Dizziness, headache, tiredness, nausea, or pain/redness at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may lead the loss of too much body water and minerals (including potassium), causing dehydration. Tell your doctor right away if you have any of these unlikely but serious symptoms of dehydration or mineral loss: muscle cramps/weakness, confusion, severe dizziness, drowsiness, unusual dry mouth/thirst, nausea/vomiting, fast/irregular heartbeat, fainting, seizures. Tell your doctor right away if you have any serious side effects, including: decreased sexual ability, chest pain, hearing problems (e.g., ringing in the ears, hearing loss), easy bruising/bleeding, stomach/abdominal pain, yellowing eyes/skin, dark urine, sudden loss of consciousness, signs of kidney problems (such as change in the amount of urine). A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using bumetanide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease (an inability to make urine), severe liver disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver problems, untreated mineral imbalance (e.g., low blood levels of sodium or potassium), gout, irregular heartbeat (e.g., ventricular arrhythmias), loss of too much body water (dehydration). This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. If you have diabetes, bumetanide may rarely make it harder to control your blood sugar. Monitor your blood sugar levels regularly and share the results with your doctor. This drug may reduce the potassium levels in your blood. Ask your doctor about adding potassium to your diet. Your doctor may prescribe a potassium supplement. Before having surgery, tell your doctor or dentist that you are taking this medication. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, the elderly may be more sensitive to the effects of this drug such as dizziness. Newborn babies, especially those that are severely ill or have a certain liver problem (jaundice), may be at greater risk for serious side effects (brain damage caused by too much bilirubin in the blood - kernicterus) while using this drug. Consult the doctor for more details. During pregnancy, this drug should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: desmopressin, lithium, probenecid. Some products have ingredients that could raise your blood pressure or worsen your swelling. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: an unusual increase in urination followed by a severe decrease in the amount of urine, severe weakness, weakness on one side of the body, slurred speech, sudden vision changes, fainting.