BRODALUMAB - INJECTION

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BRODALUMAB - INJECTION

PHONETIC PRONUNCIATION: (broe-DAL-ue-mab)

COMMON BRAND NAME(S): Siliq

GENERIC NAME(S): brodalumab

Uses

USES: This medication is used to treat plaque psoriasis. Brodalumab belongs to a class of drugs known as monoclonal antibodies. It works by blocking a certain natural protein in your body (interleukin-17A) that may cause inflammation and swelling. Brodalumab treatment may lead to reduced plaque thickness, redness, and scaling.


How to use BRODALUMAB - INJECTION

HOW TO USE: Read the Medication Guide and Instructions for Use provided by your pharmacist before you start using brodalumab and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Before treatment with this medication, your doctor will test you for tuberculosis (TB). Your doctor should also monitor you for symptoms of TB during and after treatment with this drug. If needed, treatment for TB or other infections should be given before receiving this medication. This medication is given by injection under your skin as directed by your doctor. The injection is given in the upper arms, thighs, or abdomen (except for a 2-inch area around your belly button). The dosage is based on your medical condition and response to treatment. Follow your doctor's instructions carefully. If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. Wash your hands before using this medication. Remove the medication from the refrigerator 30 minutes before you inject it to allow it to reach room temperature. Do not warm up this medication any other way such as by heating in the microwave, placing in hot water, or leaving it in direct sunlight. Do not shake the medication. The medication should be clear or slightly yellow. Before using, check this product visually for cloudiness, particles, or discoloration. If you see any of these things, do not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Do not inject into skin that is irritated, sore, bruised, red, hard, scarred, or affected by psoriasis. To lessen bruising, do not rub the injection site after a shot. Learn how to store and discard medical supplies safely. Do not reuse syringes. Use this medication regularly to get the most benefit from it. It may help to mark your calendar with a reminder. Tell your doctor if your condition does not get better or if it gets worse.

Side Effects

SIDE EFFECTS: See also Warning section. Redness, irritation, or pain at the injection site may occur. Cold symptoms (such as runny/stuffy nose, cough), tiredness, diarrhea, mouth/throat pain, muscle pain, fungal infections of the skin (such as athlete's foot, jock itch) may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough). Tell your doctor right away if you have any serious side effects, including: stomach/abdominal pain, diarrhea with blood/mucus. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using brodalumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/recent/returning infection (such as tuberculosis), bowel disease (such as Crohn's disease), mental/mood disorders (such as depression, suicidal thoughts). Brodalumab can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

SILIQ 210 MG/1.5 ML SYRINGE
SILIQ 210 MG/1.5 ML SYRINGE
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SILIQ 210 MG/1.5 ML SYRINGE
SILIQ 210 MG/1.5 ML SYRINGE
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colorless
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imprint

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Faq for BRODALUMAB - INJECTION

- Brodalumab is an injectable medication used for the treatment of moderate to severe plaque psoriasis in adults.

- Brodalumab works by inhibiting the action of interleukin-17 (IL-17), a protein involved in the body's immune response. By blocking IL-17, Brodalumab helps reduce the inflammation and symptoms associated with psoriasis.

- Brodalumab is typically administered as a 210 mg subcutaneous injection. The initial dosage may involve two injections, with subsequent injections given once every two weeks.

- Common side effects of Brodalumab may include headache, joint pain, fatigue, diarrhea, throat pain, and sinusitis. Serious side effects like changes in mood or behavior, suicidal thoughts, or severe allergic reactions are rare but possible.

- Brodalumab is not recommended for use during pregnancy as its effects on fetal development are not well-established. It is also advised to avoid breastfeeding while on Brodalumab due to the potential risks to the infant.

- The effectiveness of Brodalumab can vary from person to person. Some individuals may start experiencing improvements in their psoriasis symptoms within several weeks, while for others, it may take longer.

- Brodalumab can be used as a monotherapy or in combination with other systemic therapies or topical treatments for psoriasis. However, it's important to discuss with your healthcare provider about the potential interactions and contraindications before starting combination therapy.

- If you forget to take a dose of Brodalumab, it's recommended to administer it as soon as possible. If the next regular dose is due within a few days, you should wait and take the regular dose on schedule. Do not double the dose to make up for a missed one.

- Routine monitoring of laboratory parameters is generally not required while on Brodalumab treatment. However, your healthcare provider may still conduct periodic checks to ensure your overall health and assess the response to the medication.

Brodalumab is used to treat moderate to severe plaque psoriasis in adults who have not responded well to other treatments.

Brodalumab is administered as an injection under the skin. It is typically given by a healthcare professional, but some patients may be trained to self-inject at home.

Brodalumab is usually given once every two weeks for the first three doses, and then once every four weeks thereafter. However, dosing frequency may vary depending on individual patient response and physician's recommendation.

Brodalumab should not be used during pregnancy or while breastfeeding, as its effects on unborn babies or infants are not yet known. If you are pregnant or planning to become pregnant, or if you are breastfeeding, you should discuss alternative treatment options with your healthcare provider.

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Warning

WARNING: Rarely, brodalumab may cause serious mental/mood changes, including depression and suicidal thoughts/attempts. Get medical help right away if you have symptoms such as depression, anxiety, or thoughts of suicide. To receive this medication, all doctors, pharmacists, and patients must understand, agree to, and carefully follow the requirements of the Siliq REMS Program. These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.