BRIGATINIB - ORAL

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BRIGATINIB - ORAL

PHONETIC PRONUNCIATION: (bri-GA-ti-nib)

COMMON BRAND NAME(S): Alunbrig

GENERIC NAME(S): brigatinib

Uses

USES: Brigatinib is used to treat a certain type of lung cancer (non-small cell lung cancer). It works by slowing or stopping the growth of cancer cells.


How to use BRIGATINIB - ORAL

HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking brigatinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once daily. Swallow the tablets whole. Do not crush or chew the tablets. The dosage is based on your medical condition, response to treatment, lab tests, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor may direct you to start this medication at a lower dose for one week and may then increase your dose. Follow your doctor's instructions carefully. If you vomit after taking a dose, do not take another dose at that time. Take your next dose on your usual dosing schedule. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Side Effects

SIDE EFFECTS: Nausea/vomiting, diarrhea, decreased appetite, abdominal pain, constipation, tiredness, dizziness, fever, headache, trouble sleeping, or joint pain may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Tell your doctor right away if you have any serious side effects, including: slow heartbeat, unusual tiredness, vision changes (such as blurred vision, double vision), increased thirst/urination, unusual muscle pain/tenderness/weakness, numbness/tingling of arms/legs, signs of pancreatitis (nausea/vomiting that doesn't stop, stomach/abdominal pain). Get medical help right away if you have any very serious side effects, including: symptoms of new or worsening lung problems (such as cough, shortness of breath, chest pain). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking brigatinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, other lung/breathing problems, heart disease (such as slow heartbeat), disease of the pancreas (pancreatitis), diabetes, vision problems. This drug may make you dizzy or blur your vision. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using brigatinib. Brigatinib may harm an unborn baby. Ask your doctor about reliable forms of non-hormonal birth control (such as condoms, diaphragm with spermicide). Women using this medication should use non-hormonal birth control during treatment and for 4 months after stopping treatment. Men using this medication should use birth control during treatment and for 3 months after stopping treatment. If you or your partner become pregnant, talk to your doctor right away about the risks and benefits of this medication. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for 1 week after stopping this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of brigatinib from your body, which may affect how brigatinib works. Examples include rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

ALUNBRIG 90 MG TABLET
ALUNBRIG 90 MG TABLET
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U7
ALUNBRIG 90 MG TABLET
ALUNBRIG 90 MG TABLET
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U7
ALUNBRIG 30 MG TABLET
ALUNBRIG 30 MG TABLET
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U3
ALUNBRIG 180 MG TABLET
ALUNBRIG 180 MG TABLET
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ALUNBRIG 180 MG TABLET
ALUNBRIG 180 MG TABLET
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ALUNBRIG 90 MG-180 MG TAB PACK
ALUNBRIG 90 MG-180 MG TAB PACK
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ALUNBRIG 30 MG TABLET
ALUNBRIG 30 MG TABLET
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U3
ALUNBRIG 30 MG TABLET
ALUNBRIG 30 MG TABLET
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U3

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Faq for BRIGATINIB - ORAL

Brigatinib is an oral medication used to treat certain types of non-small cell lung cancer (NSCLC) that have a specific genetic mutation called ALK-positive.

Brigatinib works by blocking the activity of a protein called anaplastic lymphoma kinase (ALK), which is involved in the growth and spread of cancer cells. By inhibiting this protein, Brigatinib helps slow down or stop the growth of cancer cells.

The common side effects of Brigatinib may include nausea, diarrhea, fatigue, difficulty breathing, cough, headache, elevated blood pressure, and muscle pain.

Brigatinib is taken orally once a day with or without food. It is important to follow the dosage instructions provided by your doctor and avoid missing any doses. Do not crush or chew the tablets.

Brigatinib may cause harm to an unborn baby, so it is not recommended for use during pregnancy. Adequate contraception should be used by both males and females during treatment with Brigatinib to prevent pregnancy.

Brigatinib may interact with certain medications, including strong CYP3A inhibitors and inducers, certain antacids, and antifungal medications. It is important to inform your healthcare provider about all the medications you are currently taking to avoid potential interactions.

The duration of Brigatinib treatment will depend on your specific condition and how well you respond to the medication. Your doctor will determine the appropriate duration of treatment for you.

It is important to inform your healthcare provider about any pre-existing medical conditions, as well as any allergies you may have. Regular monitoring of blood pressure and liver function may be necessary during treatment with Brigatinib.

Drinking alcohol should be limited or avoided while taking Brigatinib, as it may increase the risk of certain side effects, such as liver problems and dizziness.

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Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.