BEDAQUILINE - ORAL

  • Home
  • BEDAQUILINE - ORAL

BEDAQUILINE - ORAL

PHONETIC PRONUNCIATION: (bed-AK-wi-leen)

COMMON BRAND NAME(S): Sirturo

GENERIC NAME(S): bedaquiline fumarate

Uses

USES: This medication must be used with other medications to treat active multi-drug-resistant tuberculosis (TB) of the lungs in people with limited treatment options. Bedaquiline belongs to a class of drugs known as antibiotics. It works by stopping the growth of the bacteria that causes TB. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.


How to use BEDAQUILINE - ORAL

HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking bedaquiline and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with food, as directed by your doctor, usually once daily for the first 2 weeks, followed by 3 times a week for 22 weeks. The manufacturer directs to swallow this medication whole. However, many similar drugs (immediate-release tablets) can be split/crushed. Follow your doctor's direction on how to take this medication. For the best effect, take this antibiotic at evenly spaced times. If you are taking this medication daily, take it at the same time each day. If you are taking this medication on a weekly schedule, take it on the same days of the week and at the same time of day. Mark the days on the calendar when you need to take the medication. Continue to take this medication (and other TB medications) until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early or skipping doses may allow bacteria to continue to grow, which may result in a return of the infection. Tell your doctor if your condition persists or worsens

Side Effects

SIDE EFFECTS: See also Warning section. Nausea, joint pain, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: symptoms of liver damage (such as dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, yellowing eyes/skin). Get medical help right away if you have any very serious side effects, including: coughing up blood, chest pain, fast/irregular heartbeat, severe dizziness, fainting. Bedaquiline can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, tell your doctor right away if you develop any rash. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before taking bedaquiline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease. Bedaquiline may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using bedaquiline, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using bedaquiline safely. Alcohol may increase the risk of liver disease. Avoid alcoholic beverages while using this medication. Bedaquiline may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to. Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of bedaquiline from your body, which may affect how bedaquiline works. Examples include efavirenz, rifamycins (such as rifampin, rifapentine), among others.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Images

SIRTURO 100 MG TABLET
SIRTURO 100 MG TABLET
color
white
shape
round
imprint
T 207, 100

Reviews

No Reviews Yet


Faq for BEDAQUILINE - ORAL

Bedaquiline is used as part of a combination therapy to treat multi-drug resistant tuberculosis (MDR-TB) in adults. It is not intended to be used as a single medication for the treatment of TB.

Bedaquiline works by inhibiting an enzyme called ATP synthase, which is essential for the energy production of the TB bacteria. By targeting this enzyme, Bedaquiline helps to disrupt the bacterial energy balance and eventually leads to the death of the bacteria.

Common side effects of Bedaquiline include nausea, headache, dizziness, abdominal pain, joint pain, and the discoloration of urine, sweat, and tears. These side effects are usually mild and resolve on their own.

Bedaquiline is taken orally once daily with food, preferably a light meal. It should be taken at approximately the same time each day to maintain a consistent level of the medication in the body. It is important to complete the full course of treatment as prescribed by the healthcare provider.

Yes, Bedaquiline can interact with other medications. It is important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. They can determine if any potential interactions may occur and adjust the treatment accordingly.

Bedaquiline treatment typically lasts for six months, but the duration may vary depending on the specific treatment plan prescribed by the healthcare provider. It is important to follow the recommended treatment duration and not stop taking the medication without consulting the healthcare provider.

The safety of Bedaquiline during pregnancy or breastfeeding has not been established. It is essential to discuss the potential risks and benefits of taking Bedaquiline with your healthcare provider if you are pregnant or breastfeeding before starting the medication.

Yes, Bedaquiline should be taken with food to enhance absorption. It is recommended to take it with a light meal that contains some fat for better absorption.

If you miss a dose of Bedaquiline, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

BEDAQUILINE - ORAL Pricing Page Get Discount Coupon

Warning

WARNING: This medication may increase the risk of death. It should only be used when other treatments have not worked. Bedaquiline may cause a condition that affects the heart rhythm (QT prolongation). The risk of QT prolongation may be increased if you are taking other drugs that may cause QT prolongation. (See also Precautions section).


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.