AMPHOTERICIN/LIPID COMPLEX - INJECTION

AMPHOTERICIN/LIPID COMPLEX - INJECTION

PHONETIC PRONUNCIATION: (AM-foe-TER-i-sin/LIP-id)

COMMON BRAND NAME(S): Abelcet, Ambisome, Amphotec

GENERIC NAME(S): amphotericin B lipid complex

Uses

USES: This medication is used to treat a variety of serious fungal infections. It is often used in patients who cannot tolerate or who do not respond to the regular amphotericin treatment. It works by stopping the growth of fungi.


How to use AMPHOTERICIN/LIPID COMPLEX - INJECTION

HOW TO USE: This medication is usually given by injection into a vein as directed by your doctor, usually once a day. It should be injected slowly over 2 hours. Dosage is based on your medical condition, weight, and response to therapy. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely. It may be necessary to continue this medication for several weeks to several months in order to treat certain infections. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition persists or worsens.

Side Effects

SIDE EFFECTS: Fever, shaking, chills, flushing, loss of appetite, dizziness, nausea, vomiting, headache, shortness of breath, or fast breathing may occur 1 to 2 hours after the infusion is started. In some cases, other medications (e.g., acetaminophen, diphenhydramine, corticosteroids such as hydrocortisone) may be necessary to prevent or relieve these side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: swelling/pain at injection site, muscle/joint pain, unusual tiredness, weakness, muscle cramping, signs of kidney problems (such as change in the amount of urine, painful urination), numbness/tingling of arms/legs, vision changes, hearing changes (e.g., ringing in the ears), dark urine, severe stomach/abdominal pain, yellowing eyes/skin, swelling ankles/feet, fast/slow/irregular heartbeat, cold sweats, blue lips, easy bruising/bleeding, other signs of infection (e.g., fever, persistent sore throat), mental/mood changes, seizures, black stools, vomit that looks like coffee grounds. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: Before using amphotericin/lipid complex, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: white blood cell (leukocyte) transfusions, heart disease (e.g., irregular heartbeat, congestive heart failure), liver disease, kidney disease. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: anti-cancer drugs (e.g., mechlorethamine, nitrogen mustard), azole antifungals (e.g., ketoconazole, itraconazole), cidofovir, digoxin, flucytosine, medications that affect the kidneys (e.g., pentamidine, tacrolimus, aminoglycosides such as gentamicin), muscle relaxants (e.g., tubocurarine), zidovudine. This medication may interfere with certain laboratory tests (including phosphate levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Faq for AMPHOTERICIN/LIPID COMPLEX - INJECTION

Amphotericin B lipid complex injection is used to treat serious fungal infections in patients who do not respond to other antifungal medications.

This medication works by binding to a specific component of fungal cell membranes, disrupting their structure and function, thus killing the fungal cells.

The common side effects may include fever, chills, headache, nausea, vomiting, loss of appetite, muscle pain, and changes in kidney function.

This medication is given intravenously (into a vein) by a healthcare professional in a hospital setting.

Inform your healthcare provider about any allergies, medical conditions, or medications you are currently taking, as certain drug interactions and health conditions may affect the use of this medication.

It is advisable to avoid alcohol during treatment with Amphotericin B lipid complex injection, as it may increase the risk of liver damage and other side effects.

The duration of treatment varies depending on the specific fungal infection being treated and the patient's response to the medication. Your healthcare provider will determine the appropriate duration for your individual situation.

Since this medication is administered by a healthcare professional, it is unlikely that you will miss a dose. However, if you do, it is important to inform your healthcare provider as soon as possible to reschedule the missed dose.

It is recommended to avoid using Amphotericin B lipid complex injection during pregnancy unless the potential benefit justifies the potential risk to the fetus. It is not known if this medication passes into breast milk, so breastfeeding should be avoided during treatment.



Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.