AMILORIDE/HYDROCHLOROTHIAZIDE - ORAL

AMILORIDE/HYDROCHLOROTHIAZIDE - ORAL

PHONETIC PRONUNCIATION: (a-MIL-oh-ride/HYE-droe-KLOR-oh-THYE-a-zide)

COMMON BRAND NAME(S): Moduretic

GENERIC NAME(S): amiloride HCl/hydrochlorothiazide

Uses

USES: This product is used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: amiloride and hydrochlorothiazide. Both medications are "water pills" (diuretics) and cause your body to get rid of extra salt and water. This effect may increase the amount of urine you make when you first start the product. Amiloride also helps to treat or prevent low blood potassium levels.


How to use AMILORIDE/HYDROCHLOROTHIAZIDE - ORAL

HOW TO USE: Take this medication by mouth with food, usually once or twice daily or as directed by your doctor. If you take this drug too close to bedtime, you may need to wake up to urinate. Therefore, it is best to take this medication at least 4 hours before your bedtime. If you have any questions about how and when to take this medication, ask your doctor or pharmacist. The dosage is based on your medical condition and response to treatment. Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take this product at least 4 hours before or at least 4 to 6 hours after these medications. Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase).

Side Effects

SIDE EFFECTS: See also Warning section. Headache, dizziness, nausea, vomiting, loss of appetite, stomach/abdominal pain, gas, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This product may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any of these unlikely but serious symptoms of dehydration or mineral loss: very dry mouth, extreme thirst, muscle cramps, weakness, fast heartbeat, severe dizziness, confusion, fainting, seizures. Tell your doctor right away if this unlikely but serious side effect occurs: joint pain. Tell your doctor right away if any of these rare but serious side effects occur: yellowing eyes/skin, dark urine, persistent nausea/vomiting, signs of kidney problems (such as change in the amount of urine), decrease in vision, eye pain. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

PRECAUTIONS: See also Warning section. Before taking this product, tell your doctor or pharmacist if you are allergic to amiloride or hydrochlorothiazide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: untreated salt/mineral imbalance (such as high potassium, low sodium level), kidney disease, liver disease, diabetes, loss of too much body water (dehydration), lupus, gout, high levels of fats in the blood (cholesterol/triglycerides). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Significant loss of body water from too much sweating, vomiting, or diarrhea can also lower your blood pressure and worsen dizziness. Drink plenty of fluids to prevent these effects and dehydration. If you are on restricted fluid intake, consult your doctor for further instructions. Contact your doctor if you are unable to drink fluids or if you have persistent diarrhea/vomiting. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness. If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet. This product may affect the potassium levels in your blood. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Hydrochlorothiazide passes into breast milk. It is unknown if amiloride passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.

Interactions

DRUG INTERACTIONS: See also How To Use and Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: cisapride, dofetilide, lithium, sodium phosphate products, other products that may affect potassium levels (such as eplerenone, tacrolimus, cyclosporine, birth control pills containing drospirenone, other diuretics like spironolactone/triamterene, ACE inhibitors like benazepril/captopril, angiotensin receptor antagonists like losartan/valsartan). Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). This medication may interfere with certain laboratory tests (including glucose tolerance testing, parathyroid test, protein-bound iodide test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting, slow/irregular heartbeat.

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Faq for AMILORIDE/HYDROCHLOROTHIAZIDE - ORAL

Amiloride/Hydrochlorothiazide - Oral is a medication that is used to treat high blood pressure and fluid retention (edema) in conditions such as congestive heart failure or kidney disease.

Amiloride/Hydrochlorothiazide - Oral is a combination of two drugs - amiloride and hydrochlorothiazide. Amiloride works by helping the body get rid of excess salt and water while preventing the loss of too much potassium. Hydrochlorothiazide is a diuretic that helps the kidneys remove excess salt and water from the body, also preventing the loss of potassium.

Common side effects may include dizziness, headache, increased urination, thirst, nausea, vomiting, and muscle cramps. Notify your doctor if any of these side effects persist or worsen.

Amiloride/Hydrochlorothiazide - Oral can sometimes lead to a decrease in potassium levels, known as hypokalemia. It is important to have regular blood tests to monitor potassium levels, as too low or too high levels can be harmful to your health.

You should take Amiloride/Hydrochlorothiazide - Oral exactly as prescribed by your doctor. It is usually taken once or twice daily with food to avoid stomach upset. Drink plenty of fluids while taking this medication. Do not stop taking it without consulting your doctor.

It is generally recommended to avoid or limit alcohol consumption while taking Amiloride/Hydrochlorothiazide - Oral. Alcohol may increase the risk of side effects such as dizziness or lightheadedness.

Amiloride/Hydrochlorothiazide - Oral may interact with other drugs, including certain diuretics, corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), lithium, and digoxin. It is important to inform your doctor about all the medications you are taking to avoid potential interactions.

If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Amiloride/Hydrochlorothiazide - Oral should not be used during pregnancy unless absolutely necessary. It may harm an unborn baby. It is also not recommended while breastfeeding as the medication may pass into breast milk and harm the nursing infant. Consult your doctor for more information about the risks and benefits in your specific situation.


Warning

WARNING: This product can rarely cause high potassium levels (hyperkalemia). This effect is more likely to occur in older adults and in patients with kidney disease, diabetes, or a serious illness. Potassium levels must be closely monitored on a regular basis while taking this medication. If not treated, very high potassium levels can sometimes be fatal. Tell your doctor right away if you develop any symptoms of high potassium levels, including muscle weakness, slow/irregular heartbeat, numb/tingling skin.


Disclaimer

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.