Chickens: For the control of mortality caused by necrotic enteritis (NE) associated with
Clostridium perfringens in broiler chickens. As an aid in the treatment of chronic respiratory
disease (CRD) associated with Mycoplasma gallisepticum in broiler and replacement chickens.
For the control of CRD associated with Mycoplasma gallisepticum at the time of vaccination or
other stress in chickens. For the control of CRD associated with Mycoplasma synoviae in broiler
chickens.
Turkeys: For the reduction in severity of effects of infectious sinusitis associated with
Mycoplasma gallisepticum.
Swine: For the treatment and control of swine dysentery (SD) associated with Brachyspira
hyodysenteriae. For the treatment and control of SD associated with Brachyspira hyodysenteriae
when followed immediately by Tylovet Type A medicated article in feed. For the control of
porcine proliferative enteropathies (PPE, ileitis) associated with Lawsonia intracellularis when
followed immediately by Tylovet Type A medicated article in feed.
Honey Bees: For the control of American Foulbrood (Paenibacillus larvae).

INGREDIENTS
Tylosin (as tylosin tartrate) …………………………………………. 100 g

Dosages:
 Chickens:
  NE indication: 851 to 1,419 mg/gallon (225 to 375 ppm) in drinking water.
   CRD indications: 2,000 mg/gallon (528 ppm) in drinking water.
  Turkeys: 2,000 mg/gallon (528 ppm) in drinking water.
Swine: 250 mg/gallon (66 ppm) in drinking water.
  Honey Bees: 200 mg/colony in confectioners/powdered sugar.
Mixing Directions for Medicated Drinking Water:
Always add the water to the powder. Do not pour the powder into the water. Prepare a fresh
Tylovet Soluble solution every three days. When mixing and handling tylosin, use protective
clothing and impervious gloves. If using a water medicating pump see table below, otherwise
mix as follows:
To assure thorough dissolution, first place the contents of one pouch in a mixing container and
add one gallon of water (3785 mL) to the powder to make a concentrated solution. To make
medicated drinking water containing 250 mg/gallon (66 ppm), mix this concentrated solution
with water to make 400 gallons (1514 liters) of medicated drinking water. To make medicated
drinking water containing 851 to 1,419 mg/gallon (225 to 375 ppm), mix this concentrated
solution with water to make from 117 gallons + 51 ounces (444 liters) to 70 gallons + 64 ounces
(267 liters) of medicated drinking water, respectively. To make medicated drinking water
containing 2,000 mg/gallon (528 ppm), mix this concentrated solution with water to make 50
gallons (189 liters) of medicated drinking water.

Mixing Directions for Water Medicating Pump (1:128 inclusion)*:

*This table applies only if the water medicating pump is set to deliver 1 ounce of stock solution per gallon of drinking water.

Mixing Directions for use in Honey Bees: Mix 200 mg tylosin in 20 g confectioners/powdered sugar. Use immediately.

Chickens: NE indication: Administer medicated drinking water for a single five day period in broiler
chickens. To assure all birds receive the intended medication, only medicated water should be
available. These practices should be followed to assure both food safety and responsible
antimicrobial drug use in chickens: 1) Use in flocks exhibiting signs of a necrotic enteritis outbreak,
for example, increased mortality and lesions characteristic of necrotic enteritis upon necropsy; 2)
Administer the full dose and dosing regimen once medication is initiated; 3) Use of Tylovet Soluble
or another macrolide is not advised if additional therapy is needed beyond the original course of
medication. CRD indications: Administer medicated drinking water for three days; however,
medicated water may be administered for one to five days depending upon severity of infection.
Treated chickens must consume enough medicated water to provide 50 mg per pound of body
weight per day. Only medicated water should be available to the birds.
Turkeys: Administer medicated drinking water for three days; however, medicated water may be
administered for two to five days depending upon severity of infection. Treated turkeys must
consume enough medicated water to provide 60 mg per pound of body weight per day. Only
medicated water should be available to the birds.
Swine: SD indication: Administer medicated drinking water for 3 to 10 days, depending upon
severity of infection. Alternatively, administer medicated drinking water for 3 to 10 days, followed
by 40 to 100 g tylosin per ton of complete feed (Type C medicated feed manufactured from Tylovet
Type A medicated article) for 2 to 6 weeks. Only medicated water should be available to swine while
medicating with Tylovet Soluble. PPE indication: Administer medicated drinking water for 3 to 10
days, followed by 40 to 100 g of tylosin per ton of complete feed (Type C medicated feed
manufactured from Tylovet A medicated article) for 2 to 6 weeks. Only medicated water should be
available to swine while medicating with Tylovet Soluble.
Honey Bee Colonies: Administer three treatments of medicated confectioners sugar once weekly
for 3 weeks. The 200 mg dose is applied (dusted) over the top bars of the brood chamber.

Chickens must not be slaughtered for food within 24 hours after treatment. Do not
use in layers producing eggs for human consumption.
Turkeys must not be slaughtered for food within five days after treatment.
Swine must not be slaughtered for food within 48 hours after treatment.
Honey bees: The drug should be fed early in the spring or fall and consumed by
the bees before the main honey flow begins, to avoid contamination of
production honey. Complete treatments at least 4 weeks prior to main honey flow.

User Safety Warnings: Keep Out of Reach of Children. Avoid contact with 

human skin. Exposure to tylosin may cause a rash.

How supplied:
Tylovet® Soluble is supplied in pouches of laminated aluminum foil, 100 g of tylosin activity
per pouch; or HDPE jars with PP cap with heat sealable coating, 100 g of tylosin activity per jar.

Storage:
Store at Room Temperature, 25°C (77°F).
Excursions Permitted to 40°C/104°F. Avoid moisture.

Tylovet® Soluble
(Tylosin Tartrate)

Equivalent to 100 g (3.53 oz) tylosin base
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in chickens, turkeys, swine, and honey bees 

Macrolide Antibiotic, ANADA# 200-473, Approved by FDA Product 2220

Restricted Drug (California) - Use only as Directed
ANADA # 200-473, Approved by FDA
To report adverse effects, access medical information, or obtain additional product information, call 1-877-426-7765.
Manufactured for: Huvepharma Inc. Peachtree City, GA 30269 , Made in Bulgaria
Tylovet® is a registered trademark of Huvepharma EOOD

Lot: 00000000000 Exp. Date: 00.0000 Code: LB444v4-Tyl100-USA1017