FOR USE IN ANIMALS ONLY

Net Contents: 1000 mL

Drug Facts:

Active ingredients: Altrenogest solution 0.22% (2.2 mg/mL)

Use: For synchronization of estrus in sexually mature gilts that have had at least one estrous cycle. Treatment with altrenogest solution 0.22% results in estrus (standing heat) 4 to 9 days after completion of the 14-day treatment period.

Caution: Federal law prohibits extra-label use of this drug to enhance food and/or fiber production in animals.

Do Not Use: In gilts having a previous or current history of uterine inflammation (i.e., acute, subacute or chronic endometritis).

When Using This Product: A small percentage (less than 5%) of treated gilts may exhibit estrus (standing heat) during the 14-day treatment period. Gilts nearing estrus at the start of the 14-day treatment period may express estrus early in that period.

Dosage and Directions: While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. Connect the Matrix® Dosing Device to the solution bottle according to the dosing device instructions provided as an attachment to the Matrix® Dosing Device package.

Administer 6.8 mL (15 mg altrenogest) per gilt once daily for 14 consecutive days. Treat gilts on an individual animal basis by top-dressing MATRIX® on a portion of each gilt's daily feed allowance. To produce the desired synchronization of estrus in a group of gilts, treat all of the gilts daily for the same 14-day period.

Other Information:

• To report adverse reaction call Merck at 1-800-211-3573
• To obtain product information, including material safety data sheet (MSDS), call 1-800-441-8272.
• For additional information about adverse drug experience for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/Animal/Veterinary/SafetyHealth

www.merck-animal-health-usa.com

MERCK
Animal Health

NADA 141-222, Approved by FDA

Restricted Drug (California) - use only
as directed.
Not for Human Use

Manufactured for: Intervet Inc
(d/b/a Merck Animal Health),
Summit, NJ 07901
a subsidiary of Merck & Co.

Dosing Gun (for top dressing of swine feed)
for use with
MATRIX® (altrenogest)

NOZZLE FITTING INSTRUCTIONS

• Connect nozzle and cap to barrel and screw on 7/8 of the way.
• Position nozzle at preferred angle, then tighten cap fully.

Contain any spillage with absorbent materials such as towels. Place empty drug containers, protective gloves or other articles that come in contact with MATRIX® in a leak-resistant container for disposal in accordance with applicable federal, state and local regulations.

OPERATING INSTRUCTIONS

Use vinyl, neoprene or nitrile gloves while using or cleaning the gun and gun parts. DO NOT USE LATEX GLOVES.

• Remove the shipping cap and seal on MATRIX® (altrenogest) bottle. Store the cap in a clean and dry location.
• Apply downward force and fasten the quick connect cap with dip tube onto the product bottle. (The flexible dip tube will contact the bottom of the product bottle and bend slightly)
• Use the black delivery tubing to connect the barbed connectors on the spigot and on the quick–coupling connector.
• Clamp the tubing at the spots shown on the diagram.
  Connect the quick-coupling connector to the quick connect cap.
• Hold the dosing gun vertically with the nozzle on the top. Direct the opening of the nozzle away from any person and cover it with absorbent material. Slowly squeeze and release the handle until air in the barrel is expelled and product starts to come out.
• Prime the gun by expelling two (2) doses of product into a waste container or absorbent material. (Re-prime the gun by expelling two (2) doses if air is observed inside the barrel after switching to a fresh bottle or during dosing period)
• The gun is ready for dosing.
• Store the dosing gun when loaded with product for continued use at or below room temperature, 77 °F ( 25 °C).

CLEANING INSTRUCTIONS

Use vinyl, neoprene or nitrile gloves while using or cleaning the gun and gun parts. DO NOT USE LATEX GLOVES.

• The dosing gun should be disassembled and cleaned following the below instruction after every 14-day dosing period and does not need to be cleaned daily while in use.
• Unscrew the dosing cap and replace shipping cap onto the product bottle to prevent spillage.
• Place the dip tube attached on the quick connect cap into hot soapy water and flush out residual product.
• Flush with clean water. Expel the water by flushing air through.
• Remove the barrel from the dosing gun body and dry the O-ring and felt washer. Apply an adequate amount (2-3 drops) of vegetable oil with a gloved finger to coat the O-ring and felt washer. (DO NOT USE MINERAL OIL)
• Reattach the barrel to dosing gun body and store the whole assembly in a cool and dry place.
• If squeezing the dosing gun handle to dispense product becomes increasingly difficult, the O-ring and felt washer may need to be replaced.

MERCK
Animal Health

Distributed by:
Intervet Inc.
Summit
NJ 07901

MATRIX®
(altrenogest)

SOLUTION 0.22 % (2.2 mg/mL)

For complete product information, see bottle label.
For reliable drug delivery, see the Matrix Dosing
Device instructions for use.