Zevalin: An Effective Treatment for Non-Hodgkin's Lymphoma Non-Hodgkin's lymphoma (NHL) is a type of cancer that affects the lymphatic system, which is a part of the immune system. It is the seventh most common cancer in adults in the United States. Zevalin (ibritumomab tiuxetan) is a medication that has been approved by the FDA for the treatment of NHL. In this article, we will discuss its uses, dosage, demographic, side effects, interactions, and generic options. Uses of Zevalin Zevalin is used to treat relapsed or refractory low-grade or follicular B-cell NHL. It is a form of immunotherapy that uses radioactive isotopes to target cancer cells. Zevalin works by attaching to a protein called CD20, which is found on the surface of B-cells. The radioactive material then destroys the cancerous cells while sparing healthy tissue. Dosage of Zevalin Zevalin is administered as an intravenous infusion in two steps: the first step involves the administration of an injection with a non-radioactive form of the drug to see how well it is tolerated. If there are no side effects or complications, the second step involves the administration of a radioactive form of the drug. The dose of Zevalin is determined by a patient's weight and platelet counts. Demographic of Zevalin Zevalin is typically given to adults over the age of 18 who have been diagnosed with relapsed or refractory low-grade or follicular B-cell NHL. It is not recommended for use in pregnant or nursing women, or in individuals with a history of severe allergic reactions to murine proteins or proteins derived from the mouse. Side Effects of Zevalin Like all medications, Zevalin can cause side effects. Common side effects may include fatigue, fever, chills, nausea, and vomiting. Rare but serious side effects can include a decrease in blood cell counts, infection, and kidney damage. Patients receiving this medication should be monitored regularly for any adverse effects. Interactions with Other Drugs Zevalin may interact with certain other medications, including some cancer drugs and immunosuppressants. Therefore, it is important to inform your doctor about all medications you are taking, including over-the-counter medications and dietary supplements. Generic Options Currently, there is no generic version of Zevalin available in the market. The medication is protected by a patent that is expected to expire in years to come. Conclusion Zevalin is a useful medication for the treatment of low-grade or follicular B-cell NHL. It offers a targeted approach to treating cancer cells in a way that spares healthy tissue. While there are potential side effects, the benefits of using the drug may outweigh the risks. Patients should always consult their doctor to determine if Zevalin is an appropriate treatment option for them.