Zaltrap: Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options Zaltrap (Aflibercept) is a type of cancer medicine that targets the formation of blood vessels that supply nutrients to tumors. It is used in combination with other cancer drugs to treat advanced colorectal cancer that has spread to other parts of the body. This article aims to provide a comprehensive review of Zaltrap, including its uses, dosage, demographic, side effects, interactions, and generic options. Uses Zaltrap is mainly used for the treatment of advanced colorectal cancer that has spread to other parts of the body. It is given in combination with other chemotherapy drugs such as fluorouracil, leucovorin, and irinotecan. The combination is usually used when other treatments have failed to stop the cancer from progressing. Zaltrap targets a protein known as VEGF that stimulates the formation of new blood vessels around the cancerous cells to help them grow. Dosage The recommended dosage of Zaltrap is 4mg per kilogram of body weight, given by injection into a vein every two weeks. The dosage may be adjusted depending on the patient's body weight and response to treatment. The injection is given slowly over one hour on the first administration, and it can be gradually reduced to 30 minutes for subsequent doses if tolerated. Demographic Zaltrap is approved for use in adults with metastatic colorectal cancer who have previously undergone chemotherapy. It is not recommended for use in pregnant women, as it may harm the fetus. Breastfeeding women should also avoid using Zaltrap. Side Effects Common side effects of Zaltrap include: - Nausea and vomiting - Diarrhea - Mouth sores - High blood pressure - Fatigue - Loss of appetite - Headache - Weakness - Insomnia Some serious side effects that may occur during or after treatment with Zaltrap include: - Blood clots - Heart attack - Stroke - Gastrointestinal perforation - Kidney damage - Severe bleeding If you experience any of the above side effects, you should seek immediate medical attention. Interactions Zaltrap may interact with other medications that you are taking, including prescription, non-prescription, and herbal products. You should inform your doctor about all the medications, supplements, and vitamins you are taking before starting the treatment with Zaltrap. It is recommended to avoid taking blood-thinning medications such as warfarin while on Zaltrap therapy. Generic Options Aflibercept is the generic name for Zaltrap. There are currently no FDA approved generic versions of Zaltrap available in the U.S. market. However, there may be other similar drugs prescribed by your doctor to treat advanced colorectal cancer. Opting for a generic drug over Zaltrap may be a cheaper alternative to treatment. Conclusion Zaltrap is a cancer medicine that is used in combination with other drugs to treat advanced colorectal cancer that has spread to other parts of the body. It targets the formation of blood vessels that supply nutrients to tumors. It has been linked to various side effects and may interact with other medications that you are taking. Generic options for the drug may not be available in the U.S. market, but there are alternatives that your doctor may prescribe. It is important to seek medical advice before using Zaltrap and to inform your doctor of any other medications you are taking.