Vaxchora – Key Information and Guidelines Vaxchora is a live attenuated vaccine administered orally to prevent cholera caused by Vibrio cholerae serogroup O1. The vaccine was approved by the FDA in 2016 for people aged 18 to 64 years, intending to travel to cholera-affected areas. Here is a detailed overview of Vaxchora, including its uses, dosages, demographics, side effects, interactions, and generic options. Uses of Vaxchora As an attenuation vaccine, Vaxchora works by weakening a disease-causing organism, increasing the body's immunity to prevent cholera. Cholera is a bacterial infection occurring in regions with poor sanitation and a lack of clean water supply. The condition causes severe watery diarrhea and can be fatal if not treated on time. Vaxchora is an oral vaccine that helps prevent cholera in populations traveling to endemic regions rife with cholera outbreaks. Dosage and Administration Vaxchora is administered orally as a single 100mg dose at least ten days before travel to a cholera-endemic region. The vaccine comes in a kit with an oral dosing applicator that delivers the vaccine directly to the back of the tongue to avoid inactivation in the stomach. The vaccine should be stored at 2-8°C before use; after reconstitution, it must be used immediately or within 30 minutes. Demographics for Vaxchora Vaxchora is recommended for people aged 18 to 64 years intending to travel to a cholera-endemic region. However, the vaccine is not recommended for pregnant or breastfeeding women, immunocompromised individuals, or those with a history of allergies to the vaccine or any of its components. Side Effects of Vaxchora Clinical trials of Vaxchora have shown that the vaccine has a high safety profile, and the most common adverse reactions were: - headache - abdominal pain - nausea - vomiting - tiredness The side effects are mild to moderate and usually resolve without medical intervention. However, in rare cases, severe allergic reactions have been reported, and individuals experiencing anaphylaxis after the vaccine should seek medical attention immediately. Interactions of Vaxchora Vaxchora can be coadministered with other vaccines, including the oral typhoid vaccine. However, it is essential to inform your healthcare provider of any medications or underlying medical conditions before receiving the vaccine. Individuals with a weakened immune system or those receiving immunosuppressive therapy should not receive Vaxchora. Generic Options for Vaxchora There are no generic options for Vaxchora at the moment, and the vaccine is only available as a branded product. However, the cost of the vaccine varies among providers, and individuals can contact their healthcare provider or travel clinic for the latest information on pricing and insurance coverage. Conclusion Vaxchora is an effective and safe vaccine that helps protect individuals traveling to cholera-endemic regions from the severe infection caused by Vibrio cholerae serogroup O1. The vaccine is administered orally, and a single 100mg dose is recommended at least ten days before travel. Although the vaccine has a high safety profile, individuals should discuss their medical history and any underlying conditions with their healthcare provider before receiving the vaccine.