Trulance: An Effective Medication for Chronic Idiopathic Constipation Chronic idiopathic constipation is a common health issue, affecting approximately 14% of the global population, particularly older adults, and can have a significant impact on an individual’s quality of life. When it comes to treatment, patients and healthcare providers often seek effective and well-tolerated approaches. Trulance (plecanatide) is an FDA-approved medication that can provide a long-term solution to chronic idiopathic constipation. This article will cover the uses, dosage, demographic, side effects, interactions, and generic options of Trulance. Uses Trulance is classified as a guanylate cyclase-C agonist and works by increasing the concentration of cyclic guanosine monophosphate (cGMP). This leads to the activation of chloride channels in the intestinal epithelium, resulting in increased fluid secretion and smooth muscle contraction. Trulance is prescribed to adults who suffer from chronic idiopathic constipation, a condition that causes infrequent bowel movements, straining, and hard stools. Dosage Trulance is taken orally once a day before eating. The recommended dose is 3mg per day, and treatment can last up to 12 weeks. Healthcare providers may adjust the dosage based on the patient’s age, general health, and response to the medication. Also, people who are more prone to diarrhea may require a lower dose, while those who need more effective relief may be prescribed a higher one. Demographic Trulance is approved for use in adults aged 18 years and older. It is not recommended for children, pregnant women and those who are breastfeeding. There is no medical evidence of Trulance’s effectiveness or safety for individuals with severe renal or hepatic impairment. Overall, Trulance is generally well-tolerated by most patients. Side Effects Trulance can cause various side effects, including diarrhea, abdominal pain, nausea, gas, headache, and vomiting. Most of these adverse effects are not serious and tend to disappear spontaneously within a few days. Patients who experience severe or persistent side effects should seek medical attention promptly. Interactions Trulance has been shown to interact with medications such as ketoconazole and erythromycin, which inhibit the P-glycoprotein transporter. This can lead to elevated levels of Trulance in the body, which can increase the risk of side effects. Healthcare providers should be informed if a patient is taking any medication. Generic options Plecanatide is the generic name for Trulance medication. However, it is not yet available as a generic medication in the market. It may be available soon after the expiration of Trulance's patent in the near future. Patients can ask their healthcare providers about other options available in the market. Conclusion Trulance is an effective and well-tolerated medication for the long-term treatment of chronic idiopathic constipation. This FDA-approved medication works by increasing the concentration of cyclic guanosine monophosphate (cGMP) and activating chloride channels in the intestinal epithelium, resulting in increased fluid secretion and smooth muscle contraction. While Trulance can lead to various side effects and interact with other medications, it is generally safe and rarely causes severe adverse events. Therefore, patients who suffer from chronic idiopathic constipation should discuss with a healthcare provider to determine if Trulance is a suitable treatment option.