Tracleer: Uses, Dosage, Demographic, Side Effects, Interactions and Generic Options Tracleer (bosentan) is a medication that prevents blood vessels from constricting, thereby enhancing blood flow. Tracleer is primarily used to treat pulmonary arterial hypertension (PAH), which is a progressive, debilitating, and potentially fatal rare blood vessel disorder that affects the lungs. Tracleer is also used to treat Digital ulcers (DU) in systemic sclerosis (SSc) patients. The following article will explore the uses, dosage, demographic, side effects, interactions, and generic options of Tracleer in more detail. Uses Tracleer works by lowering blood pressure in the lungs, allowing blood to flow more easily. It relaxes and expands the blood vessels supplying the lungs, reducing pressure and improving blood flow in people with PAH. PAH is a high blood pressure in the pulmonary arteries that connect the heart to the lungs, making it harder for blood to flow through them. PAH can cause shortness of breath, fainting, and chest pain. It can also damage the heart and lungs over time, leading to heart failure and other health complications. Tracleer is also used to treat Digital Ulcers in people with systemic sclerosis (SSc), a rare autoimmune disorder that causes the skin and connective tissues to thicken and tighten. SSc can cause problems with the blood vessels, which can lead to the formation of painful ulcers on the fingers and toes called Digital ulcers (DU). Tracleer can help prevent these ulcers from forming. Dosage The maximum recommended daily dosage of Tracleer is 125 mg, taken twice daily. The initial dose for adults is 62.5mg twice daily. After four weeks, the dosage should be increased to 125 mg twice daily if the patient is tolerating the medication. The dose should be adjusted based on the individual's response to the medication. Demographic Tracleer is approved for use in adults and children who are 3 years of age and older. PAH is more common in women than in men, and it occurs most often in people between the ages of 30 and 60. SSc and Digital ulcers affect more women than men and are most common in people who are aged between 20 and 50. Side Effects Tracleer can cause some potentially serious side effects, including liver damage. It is essential to monitor liver function regularly, particularly during the first few months of treatment. Symptoms that could indicate liver damage include abdominal pain, yellow eyes or skin, dark urine, and pale stools. Other side effects of Tracleer include headache, flushing, low blood pressure, respiratory infections, and ankle swelling. Rare side effects include vision disturbances, heart problems, decreased white blood cell count, and suicidal thoughts. Patients experiencing any of these should contact their doctor immediately. Interactions Tracleer should not be taken with cyclosporine, glyburide, or simvastatin. It should also not be taken with other medicines that lower blood pressure. Tracleer can reduce the effectiveness of hormonal contraceptives, and women of childbearing age should use two forms of contraception to avoid pregnancy. Generic Options Tracleer is the brand name for the drug bosentan. Bosentan is available as a generic in some countries. The generic version of Tracleer is much more cost-effective and can save patients a considerable amount of money. In conclusion, Tracleer is an important medication for treating PAH and Digital ulcers in patients with SSc. It works by relaxing blood vessels and improving blood flow to the lungs. Patients should be closely monitored for liver damage and other side effects. Women of childbearing age should use two forms of contraception to prevent pregnancy. Patients should also avoid taking Tracleer with other medications that can lower blood pressure. The generic version of Tracleer is available in some countries and can save patients a lot of money.