Syprine: A Medication for Wilson's Disease Wilson's disease is a rare genetic disorder that causes copper accumulation in the body, leading to liver and brain damage. One treatment option for this condition is Syprine (trientine hydrochloride). In this article, we will discuss Syprine's uses, dosage, demographics, side effects, interactions, and generic options. Uses Syprine is indicated for the treatment of Wilson's disease, a condition characterized by the abnormal accumulation of copper in the body. Wilson's disease results from the body's inability to eliminate excess copper, which leads to liver and brain damage. Syprine works by chelating copper and removing it from the body. Dosage Syprine is available as 250 mg capsules. The recommended dose of Syprine is 11 mg/kg/day, divided into two or three doses. For example, if a patient weighs 70 kg, the daily dose would be 770 mg (11 mg/kg/day x 70 kg). The dose may be adjusted based on the patient's response to treatment and the severity of their condition. Demographics Wilson's disease affects approximately 1 in 30,000 people worldwide and is more common in certain populations, such as those of European and Jewish ancestry. The disease typically presents in adolescents and young adults, but it can develop in people of all ages. Side Effects Side effects associated with Syprine treatment include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. Some patients may develop a skin rash, fever, or anemia. Syprine may also cause abnormal liver function tests. Patients who experience any side effects should contact their healthcare provider. Interactions Syprine may interact with other medications, including antacids, iron supplements, and vitamins that contain iron. These medications should be taken at least two hours before or two hours after Syprine to avoid reducing its effectiveness. Syprine may also interact with certain antibiotics and antifungal medications, so patients should inform their healthcare provider of all medications they are taking. Generic Options Syprine is the brand name of trientine hydrochloride. There are currently no generic versions of Syprine available in the United States. However, a compounded version of trientine hydrochloride is available from some pharmacies. Compounded medications are made to order by a pharmacist and are not FDA-approved. Patients should speak with their healthcare provider about the potential risks and benefits of using a compounded medication. Conclusion Syprine is a medication used to treat Wilson's disease, a rare genetic disorder characterized by the accumulation of copper in the body. The recommended dose of Syprine is based on weight and divided into two or three doses. Syprine may cause side effects, such as nausea and vomiting, and may interact with other medications. While there are currently no generic versions of Syprine available, a compounded version of trientine hydrochloride is available from some pharmacies. Patients should speak with their healthcare provider about the risks and benefits of Syprine and any other treatment options.