Sirturo
PHONETIC PRONUNCIATION: Sirturo
Description
Sirturo: An Overview Sirturo (bedaquiline) is an antimycobacterial drug used for the treatment of tuberculosis (TB). It was developed by Janssen Pharmaceutica, a subsidiary of Johnson & Johnson, and was approved by the US Food and Drug Administration (FDA) in 2012 as part of a combination therapy for pulmonary multi-drug resistant tuberculosis (MDR-TB). Uses of Sirturo Sirturo is used in combination with other drugs to treat MDR-TB in adults, which is a form of TB that is resistant to at least two of the four first-line anti-TB drugs (isoniazid, rifampicin, ethambutol, and pyrazinamide). It is not recommended for use in children and pregnant women. Dosage of Sirturo The recommended dosage of Sirturo is 400 mg (four 100 mg tablets) once daily for the first two weeks, followed by 200 mg (two 100 mg tablets) three times a week for the next 22 weeks, for a total duration of 24 weeks. It should be taken with food and in combination with other anti-TB drugs. Demographic Considerations Sirturo is not recommended for use in children, pregnant women, or people with severe liver or kidney disease. It should be used with caution in people with a history of heart problems or arrhythmias. Side Effects of Sirturo Sirturo can cause several side effects, including: - Nausea - Vomiting - Abdominal pain - Headache - Dizziness - Insomnia - Depression - Joint pain - Skin rash - Increased risk of QT prolongation (a heart rhythm disorder) If you experience any of these side effects, you should contact your healthcare provider immediately. Interactions with Other Drugs Sirturo can interact with several other drugs, including: - Antacids - Rifampin - Isoniazid - Ketoconazole - Erythromycin - Clarithromycin - Fluconazole It is important to inform your healthcare provider of all the medications you are taking before starting Sirturo. Generic Options There are currently no generic versions of Sirturo available. However, the patent for the drug is set to expire in 2023, which could lead to the development of generic versions in the future. Conclusion Sirturo is an antimycobacterial drug used for the treatment of MDR-TB in adults. It is not recommended for use in children and pregnant women, and should be used with caution in people with a history of heart problems. It can cause several side effects and can interact with other medications, so it is important to inform your healthcare provider of all the medications you are taking before starting Sirturo.
Faq for Sirturo
Sirturo, also known as bedaquiline, is a medication used to treat tuberculosis (TB) in combination with other drugs.
Sirturo inhibits a specific enzyme called mycobacterial ATP synthase, which is essential for the survival of the tuberculosis bacteria. By inhibiting this enzyme, Sirturo helps to kill the bacteria and treat the disease.
Yes, Sirturo has shown effectiveness in treating tuberculosis. Clinical trials have demonstrated its ability to improve treatment outcomes, especially in cases of multidrug-resistant TB.
The common side effects of Sirturo include nausea, joint pain, headache, dizziness, chest pain, and heart palpitations. It is important to discuss any side effects with your healthcare provider.
Sirturo is typically taken once daily with food. It is important to follow the dosage instructions provided by your doctor and complete the full course of treatment.
No, Sirturo is not suitable for all individuals with TB. It is specifically indicated for the treatment of pulmonary multidrug-resistant tuberculosis (MDR-TB) in adults when other alternatives are not available or appropriate.
No, Sirturo is a prescription medication and cannot be obtained over-the-counter. It requires a prescription from a healthcare professional.
The use of Sirturo during pregnancy or breastfeeding is not recommended without the advice and guidance of a healthcare professional. It is important to discuss the potential risks and benefits before using the medication.
The duration of Sirturo treatment varies depending on the specific TB regimen prescribed by the healthcare provider. It is typically used for a period of 24 weeks but can be longer or shorter based on individual circumstances.
Yes, there are potential drug interactions with Sirturo. It may interact with certain medications, including anticonvulsants, antiarrhythmics, and anticoagulants. It is crucial to inform your healthcare provider about all medications you are taking to avoid any adverse interactions.