Simponi Aria is a medication that is used to treat a variety of autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease. In this article, we will discuss the different uses and dosage of Simponi Aria, as well as its demographic, side effects, interactions, and generic options. Uses Simponi Aria (golimumab) is a tumor necrosis factor (TNF) blocker that works by targeting TNF-alpha, a protein that contributes to systemic inflammation and autoimmune diseases. By blocking this protein, Simponi Aria helps to reduce inflammation and relieve the symptoms associated with autoimmune diseases. Simponi Aria is primarily used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease. It is often prescribed for patients who have not responded well to other medications or who have severe symptoms. Dosage Simponi Aria is administered as an infusion, which is given over a period of one hour. The dosage and frequency of the infusions will depend on the condition being treated. For rheumatoid arthritis, the recommended dosage of Simponi Aria is 2 mg/kg every 8 weeks. For psoriatic arthritis, the recommended dosage of Simponi Aria is 2 mg/kg every 4 weeks for the first 3 doses, and then every 8 weeks thereafter. For ankylosing spondylitis, the recommended dosage of Simponi Aria is 2 mg/kg every 4 weeks. For Crohn's disease, the recommended dosage of Simponi Aria is 200 mg administered as an initial infusion, followed by 100 mg every 4 weeks. Demographic Simponi Aria is approved for use in adults only. It is not recommended for use in children or adolescents. Patients with a history of tuberculosis or other serious infections should not take Simponi Aria. Additionally, patients who are allergic to any of the ingredients in Simponi Aria should not take this medication. Side Effects Like all medications, Simponi Aria can have side effects. The most common side effects of Simponi Aria include injection site reactions, upper respiratory infections, and headache. Other possible side effects include: - Serious infections, including tuberculosis and sepsis - Allergic reactions - Liver problems - Blood problems - Nervous system problems, including multiple sclerosis - Heart failure - Cancer, including lymphoma and skin cancer It is important to note that the risk of these side effects is low, but they can be serious. Patients who experience any of these side effects while taking Simponi Aria should contact their doctor immediately. Interactions Simponi Aria may interact with other medications, including: - Anakinra - Abatacept - Cyclophosphamide - Etanercept - Infliximab - Tocilizumab - Vaccines Patients should inform their doctor of all medications they are taking before starting Simponi Aria. Generic Options There is currently no generic version of Simponi Aria available. However, there are other similar medications, such as Humira (adalimumab) and Remicade (infliximab), which are also TNF blockers and are used to treat autoimmune diseases. Conclusion Simponi Aria is a medication that is used to treat autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease. It is administered as an infusion and works by blocking TNF-alpha to reduce inflammation and relieve symptoms. While Simponi Aria can have side effects and interactions with other medications, it is an effective treatment option for patients with severe autoimmune diseases who have not responded well to other medications.